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Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: Results of a French single center study

Abstract : The impact of HLA-DPB1 mismatches after unrelated hematopoietic stem cell transplantation (HSCT) remains controversial. We retrospectively analyzed the impact of permissive/non-permissive HLA-DPB1 mismatches on the outcome of 141 patients who underwent 10/10 HLA allelic-matched unrelated HSCT. Each pair was classified according to the 3 (TCE3) and 4-group (TCE4) algorithm based on DPB1 alleles immunogenicity. Outcome analysis revealed that TCE3 and TCE4 non-permissive HLA-DPB1 disparities were not associated with worsened overall survival, relapse risk neither risk of acute GvHD. Overall, this single center retrospective study does not confirm the adverse prognostic of non-permissive HLA-DPB1 mismatches.
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https://www.hal.inserm.fr/inserm-03349763
Contributor : Katia Gagne Connect in order to contact the contributor
Submitted on : Monday, September 20, 2021 - 5:11:30 PM
Last modification on : Wednesday, September 22, 2021 - 3:24:32 AM

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Cyrille Touzeau, Katia Gagne, Véronique Sébille, Patricia Herry, Patrice Chevallier, et al.. Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: Results of a French single center study. Human Immunology, Elsevier, 2012, 73 (7), pp.711 - 714. ⟨10.1016/j.humimm.2012.03.013⟩. ⟨inserm-03349763⟩

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