Reversal of Enantioselectivity in the Asymmetric Rhodium- versus Iridium-Catalyzed Hydroboration of Meso Substrates

Abstract : The Ir-catalyzed asymmetric hydroboration of bicyclic hydrazines with ee and chemical yields up to 64% is reported. The switch from rhodium to iridium leads systematically to opposite enantiomers in this desymmetrization reaction.
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Alejandro Pérez Luna, Martine Bonin, Laurent Micouin, Henri-Philippe Husson. Reversal of Enantioselectivity in the Asymmetric Rhodium- versus Iridium-Catalyzed Hydroboration of Meso Substrates. Journal of the American Chemical Society, American Chemical Society, 2002, 124 (41), pp.12098-12099. ⟨10.1021/ja026714m⟩. ⟨hal-02185596⟩

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