Skip to Main content Skip to Navigation
Journal articles

Al(OH)3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background

Abstract : Macrophagic myofasciitis (MMF) is a specific histopathologic lesion involved in the persistence for years of aluminum hydroxide [Al(OH)3] at the site of previous intramuscular (i.m.) injection. In order to study mechanisms involved persistence of MMF lesions, we set up an experimental model of MMF-lesion in Sprague–Dawley and Lewis rat, by i.m. injections of 10 μL of an Al(OH)3-adjuvanted vaccine. An evaluation carried out over a 12-month period disclosed significant shrinkage of MMF lesions with time. A radioisotopic study did not show significant aluminium uptake by Al(OH)3-loaded macrophages. A morphometric approach showed that Lewis rats with Th1-biased immunity had significantly smaller lesions than Sprague–Dawley rats with balanced Th1/Th2 immunity. Concluding, our results indicate that genetic determinatives of cytotoxic T-cell responses could interfere with the clearance process and condition the persistence of vaccine-induced MMF-lesions.
Document type :
Journal articles
Complete list of metadatas

http://hal.in2p3.fr/in2p3-00068499
Contributor : Dominique Girod <>
Submitted on : Friday, May 12, 2006 - 11:15:20 AM
Last modification on : Wednesday, September 16, 2020 - 4:17:40 PM

Identifiers

Collections

Citation

Francois-Jérôme Authier, S. Sauvat, C. Christov, P. Chariot, G. Raisbeck, et al.. Al(OH)3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background. Neuromuscular Disorders, Elsevier, 2006, 16, pp.347-352. ⟨10.1016/j.nmd.2006.02.004⟩. ⟨in2p3-00068499⟩

Share

Metrics

Record views

169