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Nuclear medical imaging using $\beta+\gamma$ coincidences from $^{44}$Sc radio-nuclide with liquid xenon as detection medium

Abstract : We report on a new nuclear medical imaging technique based on the measurement of the emitter location in the three dimensions with a few mm spatial resolution using β+γ emitters. Such measurement could be realized thanks to a new kind of radio-nuclides which emit a γ-ray quasi-simultaneously with the β+ decay. The most interesting radio-nuclide candidate, namely 44Sc, will be potentially produced at the Nantes cyclotron ARRONAX. The principle is to reconstruct the intersection of the classical line of response (obtained with a standard PET camera) with the direction cone defined by the third γ-ray. The emission angle measurement of this additional γ-ray involves the use of a Compton telescope for which a new generation of camera based on a liquid xenon (LXe) time projection chamber is considered. GEANT3 simulations of a large acceptance LXe Compton telescope combined with a commercial micro-PET (LSO crystals) have been performed and the obtained results will be presented. They demonstrate that a good image can be obtained from the accumulation of each three-dimensional measured position. A spatial resolution of 2.3 mm has been reached with an injected activity of 0.5 MBq for a 44Sc point source emitter.
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http://hal.in2p3.fr/in2p3-00145475
Contributor : Dominique Girod <>
Submitted on : Thursday, May 10, 2007 - 2:11:57 PM
Last modification on : Wednesday, August 19, 2020 - 4:04:02 PM

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C. Grignon, J. Barbet, M. Bardiès, T. Carlier, J.F. Chatal, et al.. Nuclear medical imaging using $\beta+\gamma$ coincidences from $^{44}$Sc radio-nuclide with liquid xenon as detection medium. 1st International Conference on Molecular Imaging Technology - EuroMedIm 2006, May 2006, Marseille, France. pp.142-145, ⟨10.1016/j.nima.2006.10.048⟩. ⟨in2p3-00145475⟩

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