Skip to Main content Skip to Navigation
Journal articles

Radiobiologic Parameters and Local Effect Model Predictions for Head-and-Neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions

Abstract : To establish the radiobiologic parameters of head-and-neck squamous cell carcinomas (HNSCC) in response to ion irradiation with various linear energy transfer (LET) values and to evaluate the relevance of the local effect model (LEM) in HNSCC. Methods and Materials Cell survival curves were established in radiosensitive SCC61 and radioresistant SQ20B cell lines irradiated with [33.6 and 184 keV/n] carbon, [302 keV/n] argon, and X-rays. The results of ion experiments were confronted to LEM predictions. Results The relative biologic efficiency ranged from 1.5 to 4.2 for SCC61 and 2.1 to 2.8 for SQ20B cells. Fixing an arbitrary D0 parameter, which characterized survival to X-ray at high doses (>10 Gy), gave unsatisfying LEM predictions for both cell lines. For D0 = 10 Gy, the error on survival fraction at 2 Gy amounted to a factor of 10 for [184 keV/n] carbon in SCC61 cells. We showed that the slope (smax) of the survival curve at high doses was much more reliable than D0. Fitting smax to 2.5 Gy−1 gave better predictions for both cell lines. Nevertheless, LEM could not predict the responses to fast and slow ions with the same accuracy. Conclusions The LEM could predict the main trends of these experimental data with correct orders of magnitude while smax was optimized. Thus the efficiency of carbon ions cannot be simply extracted from the clinical response of a patient to X-rays. LEM should help to optimize planning for hadrontherapy if a set of experimental data is available for high-LET radiations in various types of tumors.
Complete list of metadatas

Cited literature [10 references]  Display  Hide  Download

http://hal.in2p3.fr/in2p3-00321614
Contributor : Dominique Girod <>
Submitted on : Tuesday, September 16, 2008 - 9:58:37 AM
Last modification on : Wednesday, July 8, 2020 - 12:42:07 PM
Long-term archiving on: : Thursday, June 3, 2010 - 7:50:04 PM

File

in2p3-00321614.pdf
Files produced by the author(s)

Identifiers

Citation

M. Beuve, G. Alphonse, M. Maalouf, A. Colliaux, P. Battiston-Montagne, et al.. Radiobiologic Parameters and Local Effect Model Predictions for Head-and-Neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions. International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2008, 71, pp.635-642. ⟨10.1016/j.ijrobp.2007.10.050⟩. ⟨in2p3-00321614⟩

Share

Metrics

Record views

603

Files downloads

1170