The molten salt reactor is one of the six concepts retained by the Generation IV forum in 2001. Based on the MSRE and MSBR concepts developed by ORNL in the 60s which involve a liquid fuel constituted of fluorine molten salt at a temperature close to 600 8C, new developments with innovative approach and technology have been realized which contribute to strongly improve the concept. The thorium breeder potentiality is closely related to the use of a liquid fuel which is able to be periodically treated. A reprocessing scheme has been established to treat used fuel by extraction of fission products. According to the Gen IV philosophy for closed cycle nuclear reactor, the actinides are sent back in the reactor core. In this way, the wastes radiotoxicity is strongly decreased and the use of natural resource is optimized. This paper describes an innovative reactor concept, the TMSR-NM (non-moderated thorium molten salt reactor), from the nuclear physic point of view and the different steps involving in the reprocessing scheme from the chemical point of view.