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Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study

Abstract : We report on a comparative study by Transmission Electron Microscopy (HRTEM) and Scanning Transmission Ion Microscopy (STIM) combined with Rutherford Backscattering Spectrometry (RBS) and Particle Induced X-Ray Emission (PIXE) on ultra-thin and thin cross-sections, respectively, of various skin samples (porcine skin, healthy human skin, human skin grafted on a severe combined immuno-deficient mouse model) to which we applied topically various formulations containing titanium dioxide (TiO2) nanoparticles with primary particle sizes in the range from 20-100 nm. Whereas the HRTEM and STIM/PIXE images reveal clear differences - mainly related to the different thickness of the cross-sections - they unambiguously show that penetration of TiO2 nanoparticles is restricted to the topmost 3-5 corneocyte layers of the stratum corneum (SC).
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http://hal.in2p3.fr/in2p3-00355163
Contributor : Virginie Mas <>
Submitted on : Thursday, January 22, 2009 - 4:07:26 PM
Last modification on : Thursday, January 11, 2018 - 6:12:51 AM

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E. Gontier, M. Ynsa, T. Biacuteroacute, J. Hunyadi, B. Kiss, et al.. Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicology, Taylor & Francis, 2008, 2, pp.218-231. ⟨10.1080/17435390802538508⟩. ⟨in2p3-00355163⟩

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