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Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility

Abstract : Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucleaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
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http://hal.in2p3.fr/in2p3-00373963
Contributor : Virginie Mas <>
Submitted on : Tuesday, April 7, 2009 - 3:54:10 PM
Last modification on : Tuesday, May 19, 2020 - 9:14:12 AM

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S. Incerti, H. Seznec, M. Simon, Ph. Barberet, P. Moretto. Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility. Radiation Protection Dosimetry, Oxford University Press (OUP), 2009, 133, pp.2-11. ⟨10.1093/rpd/ncp003⟩. ⟨in2p3-00373963⟩

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