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Elemental maps in human allantochorial placental vessels cells. 4. Isoproterenol and sodium nitroprusside effects

Abstract : The ionic channels (particularly, K+ and Ca2+ channels) regulate, via the membrane potential, the ionic distribution into the vascular cells. Micro-particule induced X-ray emission (PIXE) analysis was applied to determine the ionic composition of vascular smooth muscle cells (VSMCs) and of vascular endothelial cells (VECs) in the placental human allantochorial vessels in a physiological medium (Hanks' solution) modified by the addition of a NO donor (sodium nitroprusside, SNP) and of a beta-adrenergic stimulator (isoproterenol, ISO). The addition of SNP or ISO induced no modification of the Na, K, Cl, P, S, Mg and Ca concentrations in VSMCs. In VECs, a same effect was observed except an increase of the Mg concentration with ISO. Theses results indicated a retroactive control (active feedback) of the internal ionic distribution by endothelial factors, ionic channels and exchangers.
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http://hal.in2p3.fr/in2p3-00410278
Contributor : Virginie Mas <>
Submitted on : Thursday, August 20, 2009 - 9:26:58 AM
Last modification on : Tuesday, December 11, 2018 - 1:22:54 AM

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A. Guiet-Bara, C. Michelet-Habchi, P. Barberet, R.K. Dutta, Ph. Moretto, et al.. Elemental maps in human allantochorial placental vessels cells. 4. Isoproterenol and sodium nitroprusside effects. Cellular and Molecular Biology, R. Wegmann, 2004, 50, pp.609-615. ⟨in2p3-00410278⟩

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