Skip to Main content Skip to Navigation
Journal articles

Methylene Blue Dye, an Accurate Dye for Sentinel Lymph Node Identification in Early Breast Cancer

Abstract : The aim of this prospective study was to analyze the safety of methylene blue dye (MBD) and compare its efficacy with that of isotopic mapping for sentinel lymph node (SLN) identification in breast cancer. Patients and Methods: The SLN procedure, involving isotopic mapping and MBD (subareolar intraparenchymal injections of 2 mL, 10 mg/mL), was performed on 100 patients with early breast cancer. Results: The procedure was safe with a success rate of 99%; SLNs were, respectively, found in 65% by MBD, in 73% by lymphoscintigraphy and in 94% by gamma-probe. Out of 40 metastatic SLNs, 37 were “hot” and 32 stained. Digital examination allowed the detection of 2 additional metastatic LNs. Conclusion: MBD is safe and combination mapping associated with digital examination is the superior method. Modification of the procedure, favouring injections of dilute MBD (4 mL, 1.25 mg/mL) increases MBD efficiency (90%) and maintains low rates of complications
Document type :
Journal articles
Complete list of metadatas

http://hal.in2p3.fr/in2p3-00437684
Contributor : Yvette Heyd <>
Submitted on : Tuesday, December 1, 2009 - 2:55:11 PM
Last modification on : Wednesday, June 3, 2020 - 2:02:02 PM

Identifiers

  • HAL Id : in2p3-00437684, version 1

Collections

Citation

C. Mathelin, S. Croce, D. Brasse, B. Gairard, Mohamed Gharbi, et al.. Methylene Blue Dye, an Accurate Dye for Sentinel Lymph Node Identification in Early Breast Cancer. Anticancer Research, International Institute of Anticancer Research, 2009, 29, pp.4119-4125. ⟨in2p3-00437684⟩

Share

Metrics

Record views

172