Skip to Main content Skip to Navigation
Journal articles

A 3D mechanical model of the early mammalian embryo

Abstract : The early development of the mammalian embryo leads to the formation of a structure composed by an outer layer of polarized cells surrounding an inner mass of nonpolarized cells. Experimental biology has shown that this organization results from changes in cell polarity, cell shape and intercellular contacts at the 8 and 16-cell stages. In order to examine how the physical properties of embryo cells (adhesion, cortical tension) influence the organization of the cells within the embryo, our team has developed a 3D mechanical model of the dividing early embryo, based on cellular Potts models. In this paper we will present the principles of our simulations, the methodology used and we will show that a very simple mechanical model can reproduce the main structural features (geometry, cell arrangement) of the mammalian embryo during its early developmental stages, up to the 16-cell stage.
Complete list of metadatas

Cited literature [18 references]  Display  Hide  Download

http://hal.in2p3.fr/in2p3-00453960
Contributor : Laurent Le Guillou <>
Submitted on : Monday, February 8, 2010 - 11:35:18 AM
Last modification on : Monday, August 31, 2020 - 12:36:19 PM
Long-term archiving on: : Thursday, October 18, 2012 - 2:45:29 PM

File

JBPC-Le-Guillou-version-finale...
Files produced by the author(s)

Identifiers

  • HAL Id : in2p3-00453960, version 1

Citation

Laurent Le Guillou, Nicolas Dard, Jérôme Glisse, Bernard Maro, Sophie Louvet-Vallée, et al.. A 3D mechanical model of the early mammalian embryo. Journal of Biological Physics and Chemistry, Basel, Switzerland : Collegium Basilea (Institute of Advanced Study) ; Tbilisi : Association of Modern Scientific Investigation (AMSI), 2009, 9, pp.11. ⟨in2p3-00453960⟩

Share

Metrics

Record views

1074

Files downloads

798