Some Coulomb effects in heavy ion collisions are considered. Among them the process of muon and lepton pair creation, Coulomb and unitary corrections, statistics of multiple pair production. Effects of mul- tiple photon exchange in process of lepton pair production by linearly polarized photon on nuclei are consid- ered. This process is used for measuring the polarization of initial photon. Relativistic muon energy loss due to the light lepton pair production in the Coulomb field are calculated. Also we consider the effects of multiple photon exchange in elastic lepton scattering on unscreened atomic field and discuss the possible experimental testing.