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A rapid microwave-assisted procedure for easy access to Nx polydentate ligands for potential application in α-RIT

Abstract : Heterocycles bearing a hydrazine moiety react with bisaldehydes or bisketones to afford new Nx polydentate ligands suitable for α-radioimmunotherapy. We developed a fast and efficient method using microwave-assisted technology to obtain chelators with variable size and number of coordination centres which were fully characterized. The complexation efficiency with astatine will be assessed.
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Submitted on : Tuesday, July 26, 2011 - 5:55:24 PM
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M. Mével, E. Bodio, S. Grosjean, Gilles Montavon, J.-C. Meslin, et al.. A rapid microwave-assisted procedure for easy access to Nx polydentate ligands for potential application in α-RIT. SYNLETT, Georg Thieme Verlag, 2010, 8, pp.1215-1218. ⟨10.1055/s-0029-1219813⟩. ⟨in2p3-00611648⟩

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