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Analysis of Native Biological Surfaces Using a 100 kV Massive Gold Cluster Source

Abstract : In the present work, the advantages of a new, 100 kV platform equipped with a massive gold cluster source for the analysis of native biological surfaces are shown. Inspection of the molecular ion emission as a function of projectile size demonstrates a secondary ion yield increase of 100× for 520 keV Au4004+ as compared to 130 keV Au31+ and 43 keV C60. In particular, yields of tens of percent of molecular ions per projectile impact for the most abundant components can be observed with the 520 keV Au4004+ probe. A comparison between 520 keV Au4004+ time-of-flight-secondary ion mass spectrometry (TOF-SIMS) and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) data showed a similar pattern and similar relative intensities of lipid components across a rat brain sagittal section. The abundant secondary ion yield of analyte-specific ions makes 520 keV Au4004+ projectiles an attractive probe for submicrometer molecular mapping of native surfaces.
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Submitted on : Thursday, December 1, 2011 - 4:41:16 PM
Last modification on : Wednesday, September 16, 2020 - 4:08:14 PM

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F.A. Fernandez-Lima, J. Post, J.D. Debord, M.J. Eller, S. V. Verkhoturov, et al.. Analysis of Native Biological Surfaces Using a 100 kV Massive Gold Cluster Source. Analytical Chemistry, American Chemical Society, 2011, 82, pp.8448-8453. ⟨10.1021/ac201481r⟩. ⟨in2p3-00647222⟩



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