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Conference papers

Modeling Radiation Chemistry and Biology in the Geant4 Toolkit

M. Karamitros 1 A. Mantero S. Incerti 1 G. Baldacchino 2 P. Barberet 1 M. Bernal R. Capra C. Champion 3 Z. El Bitar 4 Z. Francis W. Friedland P. Guèye A. Ivanchenko 1 V. Ivanchenko 1 H. Kurashige B. Mascialino P. Moretto 1 P. Nieminen 5 G. Santin 5 H. Seznec 1 H. N. Tran C. Villagrasa 6 C. Zacharatou
1 IPCV - Interface Physique et Chimie pour le Vivant
CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan
2 IRAMIS - Institut Rayonnement Matière de Saclay
3 LPMC - Laboratoire de physique moléculaire et des collisions
4 IPHC - Institut Pluridisciplinaire Hubert Curien
5 ESTEC - European Space Research and Technology Centre
6 IRSN - Institut de Radioprotection et de Sûreté Nucléaire
Abstract : Simulation of biological effects of ionizing radiation at the DNA scale requires not only the modeling of direct damages induced on DNA by the incident radiation and by secondary particles but also the modeling of indirect effects of radiolytic products resulting from water radiolysis. They can provoke single and double strand breaks by reacting with DNA. The Geant4 Monte Carlo toolkit is currently being extended for the simulation of biological damages of ionizing radiation at the DNA scale in the framework of the "Geant4-DNA" project. Physics models for the modeling of direct effects are already available in Geant4. In the present paper, an approach for the modeling of radiation chemistry in pure liquid water within Geant4 is presented. In particular, this modeling includes Brownian motion and chemical reactions between molecules following water radiolysis. First results on time-dependent radiochemical yields1 from 1 picosecond up to 1 microsecond after irradiation are compared to published data and discussed.
Keywords : Geant4 Geant4-DNA DNA microdosimetry liquid water chemistry radiolysis biology radiation damage
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Conference papers
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http://hal.in2p3.fr/in2p3-00658865
Contributor : Nathalie Martin <>
Submitted on : Wednesday, January 11, 2012 - 2:58:17 PM
Last modification on : Monday, February 1, 2021 - 12:38:02 PM

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  • HAL Id : in2p3-00658865, version 1

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IN2P3 | IRSN | DRS-IPHC | CENBG | CNRS | IPHC | CEA | DSM-IRAMIS | UNIV-LORRAINE | CEA-DRF | SITE-ALSACE

Citation

M. Karamitros, A. Mantero, S. Incerti, G. Baldacchino, P. Barberet, et al.. Modeling Radiation Chemistry and Biology in the Geant4 Toolkit. 3rd Monte Carlo Conference MC2010, Oct 2010, Tokyo, Japan. pp.503-508. ⟨in2p3-00658865⟩

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