Characterization of At- species in simple and biological media by high performance anion exchange chromatography coupled to gamma detector.

Abstract : Astatine is a rare radioelement belonging to the halogen group. Considering the trace amounts of astatine produced in cyclotrons, its chemistry cannot be evaluated by spectroscopic tools. Analytical tools, provided that they are coupled with a radioactive detection system, may be an alternative way to study its chemistry. In this research work, High Performance Anion Exchange Chromatography (HPAEC) coupled to a gamma detector (γ) was used to evaluate astatine species under reducing conditions. Also, to strengthen the reliability of the experiments, a quantitative analysis using a reactive transport model has been done. The results confirm the existence of one species bearing one negative charge in the pH range 27.5. With respect to the other halogens, its behavior indicates the existence of negative ion, astatide At-. The methodology was successfully applied to the speciation of the astatine in human serum. Under fixed experimental conditions (pH 7.47.5 and redox potential of 250 mV) astatine exists mainly as astatide At- and does not interact with the major serum components. Also, the method might be useful for the in vitro stability assessment of 211At-labelled molecules potentially applicable in nuclear medicine.
Type de document :
Article dans une revue
Analytica Chimica Acta, Elsevier Masson, 2012, 721, pp.182. <10.1016/j.aca.2012.01.052>


http://hal.in2p3.fr/in2p3-00681129
Contributeur : Andrea Sabatié-Gogova <>
Soumis le : mardi 20 mars 2012 - 17:20:04
Dernière modification le : vendredi 4 décembre 2015 - 12:27:01

Fichier

ACApdf.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

A. Sabatié-Gogova, Julie Champion, Sandrine Huclier, N. Michel, F. Pottier, et al.. Characterization of At- species in simple and biological media by high performance anion exchange chromatography coupled to gamma detector.. Analytica Chimica Acta, Elsevier Masson, 2012, 721, pp.182. <10.1016/j.aca.2012.01.052>. <in2p3-00681129>

Exporter

Partager

Métriques

Consultations de
la notice

365

Téléchargements du document

197