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Journal articles
A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats
Julia Maerk
1, *
Didier Benoit
2
Laure Balasse
3
Mathieu Benoit
Jean-Claude Clémens
1
Sylvain Fieux
3
Denis Fougeron
1
J. Graber-Bolis
1
Batiste Janvier
2
Michel Jevaud
1
Aurélie Genoux
2
Pascale Gisquet-Verrier
4
Mohsine Menouni
1
Frédéric Pain
2
L. Pinot
2
Christian Tourvielle
3
Luc Zimmer
3
Christian Morel
1
Philippe Laniece
2
Julia Maerk 1
Correspondent author
Didier Benoit 2
Author
Laure Balasse 3
Author
Mathieu Benoit
Author IdHAL : mathieu-benoit ResearcherId : http://www.researcherid.com/rid/F-4708-2019 ORCID : https://orcid.org/0000-0002-0134-4863
Jean-Claude Clémens 1
Author
Sylvain Fieux 3
Author
Denis Fougeron 1
Author
J. Graber-Bolis 1
Author
Batiste Janvier 2
Author
Michel Jevaud 1
Author
Aurélie Genoux 2
Author
Pascale Gisquet-Verrier 4
Author
Mohsine Menouni 1
Author
Frédéric Pain 2
Author IdHAL : frederic-pain ORCID : https://orcid.org/0000-0001-9854-6025
L. Pinot 2
Author
Christian Tourvielle 3
Author
Luc Zimmer 3
Author
Christian Morel 1
Author
Philippe Laniece 2
Author IdHAL : philippe-laniece ORCID : https://orcid.org/0000-0003-0428-0436
1
CPPM - Centre de Physique des Particules de Marseille (163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09 - France)
- AMU - Aix Marseille Université : UMR7346 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- IN2P3 - Institut National de Physique Nucléaire et de Physique des Particules du CNRS (France)
- CNRS - Centre National de la Recherche Scientifique : UMR7346 (France)
2
IMNC (UMR_8165) - Imagerie et Modélisation en Neurobiologie et Cancérologie (Université Paris Sud - Bâtiment 440
15 rue Georges Clémenceau
91405 Orsay Cedex - France - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_8165 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_8165 (France)
- IN2P3 - Institut National de Physique Nucléaire et de Physique des Particules du CNRS (France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
3
CERMEP - Centre d'Exploration et de Recherche Médicales par Émission de Positons (59 bd Pinel, 69003 Lyon - France)
- UJF - Université Joseph Fourier - Grenoble 1 (BP 53 - 38041 Grenoble Cedex 9 - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- CHU Grenoble (France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
- CHU Saint-Etienne (France)
- UJM - Université Jean Monnet [Saint-Étienne] (10 rue Tréfilerie - 42100 Saint-Étienne - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique (France)
4
CNPS - Centre de Neurosciences Paris-Sud (Bâtiment 446 91405 ORSAY Cedex - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8195 (France)
Abstract : The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications to their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using a submillimetric probe for beta+ radiotracer detection based on a pixelated silicon diode that can be stereotaxically implanted in the brain region of interest. This fully autonomous detection system permits time-resolved high sensitivity measurements of radiotracerswith additional imaging features in freelymoving rats. An application-specific integrated circuit (ASIC) allows for parallel signal processing of each pixel and enables the wireless operation. All components of the detector were tested and characterized. The beta+ sensitivity of the system was determined with the probe dipped into radiotracer solutions.Monte Carlo simulations served to validate the experimental values and assess the contribution of gamma noise. Preliminary implantation tests on anaesthetized rats proved PIXSIC's functionality in brain tissue. High spatial resolution allows for the visualization of radiotracer concentration in different brain regions with high temporal resolution. (Some figures may appear in colour only in the online journal)
Document type :
Journal articles
Domain :
Complete list of metadatas
http://hal.in2p3.fr/in2p3-00837658
Contributor : Danielle Cristofol <>
Submitted on : Monday, June 24, 2013 - 9:11:01 AM
Last modification on : Wednesday, September 16, 2020 - 5:21:11 PM
Contributor : Danielle Cristofol <>
Submitted on : Monday, June 24, 2013 - 9:11:01 AM
Last modification on : Wednesday, September 16, 2020 - 5:21:11 PM
Identifiers
- HAL Id : in2p3-00837658, version 1
- DOI : 10.1088/0031-9155/58/13/4483
Collections
IN2P3 | HCL | CPPM | IMNC | CNRS | UGA | PRIMES | PRIMES_WP2 | UNIV-AMU | UNIV-ST-ETIENNE | UNIV-LYON1 | UNIV-PARIS7 | USPC | UDL
Citation
Julia Maerk, Didier Benoit, Laure Balasse, Mathieu Benoit, Jean-Claude Clémens, et al.. A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats. Physics in Medicine and Biology, IOP Publishing, 2013, 58, pp.4483 - 4500. ⟨10.1088/0031-9155/58/13/4483⟩. ⟨in2p3-00837658⟩
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