A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

Julia Maerk; Didier Benoit; Laure Balasse; Mathieu Benoit; Jean-Claude Clémens; Sylvain Fieux; Denis Fougeron; J. Graber-Bolis; Batiste Janvier; Michel Jevaud; Aurélie Genoux; Pascale Gisquet-Verrier; Mohsine Menouni; Frédéric Pain; L. Pinot; Christian Tourvielle; Luc Zimmer; Christian Morel; Philippe Laniece

doi:10.1088/0031-9155/58/13/4483

Journal articles

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

Julia Maerk ^{1, *} Didier Benoit ² Laure Balasse ³ Mathieu Benoit Jean-Claude Clémens ¹ Sylvain Fieux ³ Denis Fougeron ¹ J. Graber-Bolis ¹ Batiste Janvier ² Michel Jevaud ¹ Aurélie Genoux ² Pascale Gisquet-Verrier ⁴ Mohsine Menouni ¹ Frédéric Pain ² L. Pinot ² Christian Tourvielle ³ Luc Zimmer ³ Christian Morel ¹ Philippe Laniece ²

* Corresponding author

1 CPPM - Centre de Physique des Particules de Marseille

2 IMNC (UMR_8165) - Imagerie et Modélisation en Neurobiologie et Cancérologie

3 CERMEP - Centre d'Exploration et de Recherche Médicales par Émission de Positons

4 CNPS - Centre de Neurosciences Paris-Sud

Abstract : The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications to their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using a submillimetric probe for beta+ radiotracer detection based on a pixelated silicon diode that can be stereotaxically implanted in the brain region of interest. This fully autonomous detection system permits time-resolved high sensitivity measurements of radiotracerswith additional imaging features in freelymoving rats. An application-specific integrated circuit (ASIC) allows for parallel signal processing of each pixel and enables the wireless operation. All components of the detector were tested and characterized. The beta+ sensitivity of the system was determined with the probe dipped into radiotracer solutions.Monte Carlo simulations served to validate the experimental values and assess the contribution of gamma noise. Preliminary implantation tests on anaesthetized rats proved PIXSIC's functionality in brain tissue. High spatial resolution allows for the visualization of radiotracer concentration in different brain regions with high temporal resolution. (Some figures may appear in colour only in the online journal)

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Journal articles

Domain :

Life Sciences [q-bio] / Bioengineering

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http://hal.in2p3.fr/in2p3-00837658
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Submitted on : Monday, June 24, 2013 - 9:11:01 AM
Last modification on : Monday, December 14, 2020 - 6:10:43 PM

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

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A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

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