Production of Scandium-44m and Scandium-44g with Deuterons on Calcium-44: Cross Section measurements and Production Yield Calculations

Abstract : Among the large number of radionuclides of medical interest, Sc-44 is promising for PET imaging. Either the ground-state Sc-44g or the metastable-state Sc-44m can be used for such applications, depending on the molecule used as vector. This study compares the production rates of both Sc-44 states, when protons or deuterons are used as projectiles on an enriched Calcium-44 target. This work presents the first set of data for the deuteron route. The results are compared with the TALYS code. The Thick-Target production Yields of Sc-44m and Sc-44g are calculated and compared with those for the proton route for three different scenarios: the production of Sc-44g for conventional PET imaging, its production for the new 3 γ imaging technique developed at the SUBATECH laboratory and the production of a Sc-44m/Sc-44g in vivo generator for antibody labelling.
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Submitted on : Monday, August 31, 2015 - 3:04:30 PM
Last modification on : Tuesday, September 17, 2019 - 10:30:03 AM

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C. Duchemin, Arnaud Guertin, Ferid Haddad, N. Michel, Vincent Métivier. Production of Scandium-44m and Scandium-44g with Deuterons on Calcium-44: Cross Section measurements and Production Yield Calculations. Physics in Medicine and Biology, IOP Publishing, 2015, 60, pp.6847-6864. ⟨10.1088/0031-9155/60/17/6847⟩. ⟨in2p3-01188671⟩

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