PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats

Laure Balasse 1 Julia Maerk 2 Frédéric Pain 1 Aurélie Genoux 1 Sylvain Fieux 3 Françoise Lefebvre 1 Christian Morel 2 Pascale Gisquet-Verrier 4 Philippe Lanièce 1 Luc Zimmer 3
1 IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
2 CPPM - Centre de Physique des Particules de Marseille
3 UCBL - Université Claude Bernard Lyon 1
4 Neuro-PSI - Institut des Neurosciences de Paris-Saclay
Abstract : The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [ 11 C]raclopride tracer–specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.
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Submitted on : Monday, November 30, 2015 - 4:40:00 PM
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IN2P3 | CNRS | IMNC | CPPM | UNIV-AMU | PRIMES_WP2 | PRIMES | UNIV-PARIS-SACLAY | UNIV-LYON1 | UNIV-PARIS7 | USPC

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Laure Balasse, Julia Maerk, Frédéric Pain, Aurélie Genoux, Sylvain Fieux, et al.. PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats. Molecular Imaging, Decker Publishing, 2015, 14 (484–489), ⟨10.2310/7290.2015.00020⟩. ⟨in2p3-01235714⟩

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