Journal articles
PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats
Abstract : The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [ 11 C]raclopride tracer–specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.
Cited literature [15 references]
http://hal.in2p3.fr/in2p3-01235714
Contributor : Danielle Cristofol <>
Submitted on : Monday, November 30, 2015 - 4:40:00 PM
Last modification on : Wednesday, February 17, 2021 - 1:38:04 PM
Long-term archiving on: : Tuesday, March 1, 2016 - 2:30:44 PM
Contributor : Danielle Cristofol <>
Submitted on : Monday, November 30, 2015 - 4:40:00 PM
Last modification on : Wednesday, February 17, 2021 - 1:38:04 PM
Long-term archiving on: : Tuesday, March 1, 2016 - 2:30:44 PM
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LBalasse_MI_15.pdf
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