How to produce high specific activity tin-117 m using alpha particle beam

Abstract : Cd-116(α,3n)Sn-117 m. High specific activity Sn-117 m. Theranostic isotope. a b s t r a c t Tin-117m is an interesting radionuclide for both diagnosis and therapy, thanks to the gamma-ray and electron emissions, respectively, resulting from its decay to tin-117g. The high specific activity of tin-117 m is required in many medical applications, and it can be obtained using a high energy alpha particle beam and a cadmium target. The experiments performed at the ARRONAX cyclotron (Nantes, France) using an alpha particle beam delivered at 67.4 MeV provide a measurement of the excitation function of the Cd-nat(α,x)Sn-117 m reaction and the produced contaminants. The Cd-116(α,3n)Sn-117m production cross section has been deduced from these experimental results using natural cadmium. Both production yield and specific activity as a function of the projectile energy have been calculated. These informations help to optimize the irradiation conditions to produce tin-117 m with the required specific activity using α particles with a cadmium target.
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C. Duchemin, M. Essayan, Arnaud Guertin, F. Haddad, N. Michel, et al.. How to produce high specific activity tin-117 m using alpha particle beam. Applied Radiation and Isotopes, Elsevier, 2016, 115, pp.113-124. ⟨10.1016/j.apradiso.2016.06.016⟩. ⟨in2p3-01951346⟩



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