Développement de la tomographie intra-vitale au K-edge avec la caméra à pixels hybrides XPAD3

Abstract : The hybrid pixel camera XPAD3 integrated in the micro-CT PIXSCAN IIis a new device developed by the imXgam team at CPPM for which photon counting replaces charge integration used in standard X-ray CT. This novel approach involves advantages, in particular the absence of dark noise and the ability to set an energy threshold on each pixel of the detected photons. This features has been exploited during this thesis work for standard small animal preclinical imaging and permitted to establish the faisability of ex vivo, and then in vivo labelling of marcrophages. On another hand, the ability of this camera is of uppermost importance for the development of K-edge imaging approaches, which exploit spectral information on the counted photons. K-edge imaging permits to identify contrast agent compartiments with regards to bones in classical radiography. K-edge imaging is obtained by selecting, for each pixel calibration, those pixel that are set at one of the three different thresholds around the K-shell’s binding energy of the selected contrast agents and then, to proceed with a subtraction analysis to the images obtained above and below the K-edge energy. We develop a new way of calibrating the XPAD3 detector that permits to provide the proof of concept of a patent owned by the imXgam team, and to obtain the first results on living mice by dividing the acquisition time by three with a compromise on the resolution. This novel approach can be implemented in "two colours" in order to separate clearly two different contrast agents. This brings a new way to visualize biological information and to provide possible future approaches for the study of the inter-dependance of vascularisation and inflammation during the tumor development.
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Submitted on : Monday, August 31, 2015 - 10:36:47 AM
Last modification on : Thursday, January 18, 2018 - 1:55:08 AM
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  • HAL Id : tel-01188560, version 1

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C. Kronland-Martinet. Développement de la tomographie intra-vitale au K-edge avec la caméra à pixels hybrides XPAD3. Ingénierie biomédicale. AMU, 2015. Français. ⟨tel-01188560⟩

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