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Nuclear Instruments and Methods in Physics Research Research Section B: Beam Interactions with Materials and Atoms 245 (2006) 511-518
Micro-PIXE characterization of interactions between a sol-gel derived bioactive glass and biological fluids
Johnatan Lao1, Jean-Marie Nedelec2, Philippe Moretto3, Edouard Jallot1
Bioverre ANR PNANO 2005 Collaboration(s)

Bioactive glasses possess the ability to bond to living tissues through the formation of a calcium phosphate-rich layer at their interface with living tissues. This paper reports the different steps of this bioactivity process via a complete micro-PIXE characterization of a sol-gel derived SiO2-CaO bioactive glass in contact with biological fluids for different delays. Multi-elemental cartography at the glass/biological fluids interface together with major and trace elements quantification permit a better understanding of the five reaction stages involved in the bioactivity mechanisms. The presence of phosphorus was detected at the periphery of the material within 6 h of interaction with biological fluids. A calcium phosphate-rich layer containing magnesium is formed after a few days of interaction and presence of bone-like apatite is deduced from the calculation of the Ca/P ratio at the material interface. That is of deep interest for clinical applications, because this biologically active behavior results in the formation of a strong interfacial bond between the glass and host tissues, and will stimulate bone-cell proliferation.
1 :  LPC - Laboratoire de Physique Corpusculaire [Clermont-Ferrand]
2 :  LMI - Laboratoire des Matériaux Inorganiques
3 :  CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan
PIXE-RBS methods – biomaterials – bioactive glass – sol-gel.
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