| Title: |
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Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber |
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| Author(s): |
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Donald Peyrot1, Darine Abi Haidar2, Claire Lefort ( )3, Nicolas Sandeau, Tigran Mansuryan ()3, Frédéric Louradour ()3, Sergei Kruglik, Geneviève Bourg-Heckly |
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| Laboratory: |
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| Research team: |
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PHOTONIQUE |
| Abstract: |
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We are developing a non-linear fibered endomicroscope for imaging the extracellular matrix collagen and elastin fibrillar networks during bronchoscopy. As a proof of concept, laser pulses at the output of a standard 2 meter long single-mode fibre have been obtained with pulse duration of about 50 fs and pulse energy up to 50 uJ, using a specially designed grism line for the dispersion compensation. With these pulses, we performed a spectroscopic characterization of the non-linear endogenous signal, consisting of two-photon fluorescence and second harmonic generation, and originated from human pulmonary tissue of various thickness, both in forward and backward geometry of signal collection, with excitation at 830 nm. |
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| Fulltext language: |
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English |
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| Production date: |
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2011 |
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| Journal: |
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Proc. SPIE 7893 |
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| Book title: |
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Prococeedings SPIE 7893 |
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| Audience: |
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international |
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| Publication type: |
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Conference proceedings |
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| Publication date: |
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2011 |
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| Volume: |
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7893 |
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| Page, identifiant, ...: |
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n°789309 |
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| Conference or book title: |
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Endoscopic Microscopy VI, Nonlinear Endomicroscopy |
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| Conference date: |
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2011-01-23 |
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| Conference date (end): |
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2011-01-23 |
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| City: |
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San franscisco - Californie |
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| Country: |
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United States |
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