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PIXSIC: A Pixellated Beta-Microprobe for Kinetic Measurements of Radiotracers on Awake and Freely Moving Small Animals
Godart J., Weiss P., Chantepie B., C. Clemens J., Delpierre P. et al
IEEE Tansactions on Nuclear Science 57 (2010) 998-1007 - http://hal.in2p3.fr/in2p3-00529435
Life Sciences/Bioengineering
Life Sciences/Animal biology
PIXSIC: A Pixellated Beta-Microprobe for Kinetic Measurements of Radiotracers on Awake and Freely Moving Small Animals
J. Godart1, P. Weiss ()2, B. Chantepie2, J. C. Clemens2, P. Delpierre2, B. Dinkespiler2, B. Janvier1, M. Jevaud2, S. Karkar2, F. Lefebvre1, R. Mastrippolito1, M. Menouni2, F. Pain1, P. Pangaud2, L. Pinot1, C. Morel2, P. Laniece1
1:  IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
CNRS : UMR8165 – IN2P3 – Université Paris XI - Paris Sud – Université Paris VII - Paris Diderot
BATIMENT 104 15 Rue Georges Clémenceau 91406 ORSAY CEDEX
2:  CPPM - Centre de Physique des Particules de Marseille
CNRS : UMR7346 – IN2P3 – Université de la Méditerranée - Aix-Marseille II
163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09
We present a design study of PIXSIC, a new B^+ radiosensitive microprobe implantable in rodent brain dedicated to in vivo and autonomous measurements of local time activitycurves of beta radiotracers in a small (a few mm^3 ) volume of brain tissue. This project follows the initial β microprobe previously developed at IMNC, which has been validated in several neurobiological experiments. This first prototype has been extensively used on anesthetized animals, but presents some critical limits for utilization on awake and freely moving animals. Consequently, we propose to develop a wireless setup that can be worn by an animal without constraints upon its movements. To that aim, we have chosen a Silicon-based detector, highly β sensitive, which allows for the development of a compact pixellated probe (typically 600 X 200 X1000 μm^3), read out with miniaturized wireless electronics. Using Monte-Carlo simulations, we show that high resistive Silicon pixels are appropriate for this purpose, assuming that the pixel dimensions are adapted to our specific signals. More precisely, a tradeoff has to be found between the sensitivity to β^+ particles and to the 511 keV γ background resulting from annihilations of β^+ with electrons. We demonstrate that pixels with maximized surface and minimized thickness can lead to an optimization of their β^+ sensitivity with a relative transparency to the annihilation background

Article in peer-reviewed journal
IEEE Tansactions on Nuclear Science
2010 IEEE

Anesthesia bias – beta microprobe – freely moving – intra-cerebral probe – PET imaging – silicon pixel detectors – small animal imaging – wireless measurements