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GATE V6: a major enhancement of the GATE simulation platform enabling modelling of CT and radiotherapy
Jan S., Benoit D., Becheva E., Carlier T., Cassol F. et al
Physics in Medicine and Biology 56 (2011) 881-901 - http://hal.in2p3.fr/in2p3-00559709
Life Sciences/Bioengineering/Biomaterials
GATE V6: a major enhancement of the GATE simulation platform enabling modelling of CT and radiotherapy
S. Jan1, D. Benoit2, E. Becheva1, T. Carlier3, 4, F. Cassol5, P. Descourt6, T. Frisson3, L. Grevillot3, L. Guigues3, L. Maigne7, C. Morel5, Y. Perrot7, N. Rehfeld2, D. Sarrut3, D. R Schaart, S. Stute2, U. Pietrzyk, D. Visvikis6, N. Zahra3, I. Buvat ()2
1:  LIME - Laboratoire d'Imagerie Moléculaire Expérimentale
CEA : DSV/I2BM
France
2:  IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
CNRS : UMR8165 – IN2P3 – Université Paris XI - Paris Sud – Université Paris VII - Paris Diderot
BATIMENT 104 15 Rue Georges Clémenceau 91406 ORSAY CEDEX
France
3:  CREATIS - Centre de recherche en applications et traitement de l'image pour la santé
http://www.creatis.insa-lyon.fr/
Institut National des Sciences Appliquées [INSA] – CNRS : UMR5220 – Université Claude Bernard - Lyon I (UCBL) – INSERM : U1044 – Hospices Civils de Lyon
7 avenue Jean Capelle, Bat Blaise Pascal, 69621 Villeurbanne Cedex
France
4:  CRCNA - Centre de Recherche en Cancérologie Nantes - Angers
INSERM : U892 – CNRS : UMR6299 – Hôtel-Dieu de Nantes – Université de Nantes
1 Place Alexis-Ricordeau, 44000 Nantes
France
5:  CPPM - Centre de Physique des Particules de Marseille
http://marwww.in2p3.fr/
CNRS : UMR7346 – IN2P3 – Université de la Méditerranée - Aix-Marseille II
163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09
France
6:  LaTIM - Laboratoire de Traitement de l'Information Medicale
http://latim.univ-brest.fr
Université de Bretagne Occidentale (UBO) – Institut Mines-Télécom – Télécom Bretagne – CHU Brest – PRES Université Européenne de Bretagne (UEB) – INSERM : UMR1101
CHRU Morvan, Bâtiment 1, 1er étage, bureau 1056, 2 avenue Foch, 29609 Brest, France
France
7:  LPC - Laboratoire de Physique Corpusculaire [Clermont-Ferrand]
http://clrwww.in2p3.fr/
CNRS : UMR6533 – IN2P3 – Université Blaise Pascal - Clermont-Ferrand II
Campus des Cézeaux 24, avenue des Landais BP 80026 63171 Aubière Cedex
France
GATE (Geant4 Application for Emission Tomography) is a Monte Carlo simulation platform developed by the OpenGATE collaboration since 2001 and first publicly released in 2004. Dedicated to the modelling of planar scintigraphy, single photon emission computed tomography (SPECT) and positron emission tomography (PET) acquisitions, this platform is widely used to assist PET and SPECT research. Arecent extension of this platform, released by the OpenGATE collaboration as GATE V6, now also enables modelling of x-ray computed tomography and radiation therapy experiments. This paper presents an overview of the main additions and improvements implemented in GATE since the publication of the initial GATE paper (Jan et al 2004 Phys. Med. Biol. 49 4543–61). This includes new models available in GATE to simulate optical and hadronic processes, novelties in modelling tracer, organ or detector motion, new options for speeding up GATE simulations, examples illustrating the use of GATE V6 in radiotherapy applications and CT simulations, and preliminary results regarding the validation of GATE V6 for radiation therapy applications. Upon completion of extensive validation studies, GATE is expected to become a valuable tool for simulations involving both radiotherapy and imaging.

Article in peer-reviewed journal
2011
Physics in Medicine and Biology (Phys Med Biol)
Publisher Institute of Physics: Hybrid Open Access
ISSN 0031-9155 (eISSN : 1361-6560)
56
881-901
2011 Institute of Physics and Engineering in Medicine Printed in the UK