| Titre : |
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Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber |
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| Auteur(s) : |
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Donald Peyrot1, Darine Abi Haidar2, Claire Lefort ( )3, Nicolas Sandeau, Tigran Mansuryan ()3, Frédéric Louradour ()3, Sergei Kruglik, Geneviève Bourg-Heckly |
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| Laboratoire : |
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| équipe(s) de recherche : |
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PHOTONIQUE |
| Résumé : |
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We are developing a non-linear fibered endomicroscope for imaging the extracellular matrix collagen and elastin fibrillar networks during bronchoscopy. As a proof of concept, laser pulses at the output of a standard 2 meter long single-mode fibre have been obtained with pulse duration of about 50 fs and pulse energy up to 50 uJ, using a specially designed grism line for the dispersion compensation. With these pulses, we performed a spectroscopic characterization of the non-linear endogenous signal, consisting of two-photon fluorescence and second harmonic generation, and originated from human pulmonary tissue of various thickness, both in forward and backward geometry of signal collection, with excitation at 830 nm. |
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Langue du texte
intégral : |
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Anglais |
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Date de production,
écriture : |
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2011 |
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| Journal : |
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Proc. SPIE 7893 |
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| Titre de l'ouvrage : |
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Prococeedings SPIE 7893 |
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| Audience : |
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internationale |
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| Type de publication : |
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Communications avec actes |
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| Date de publication : |
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2011 |
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| Volume : |
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7893 |
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| Page, identifiant, ... : |
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n°789309 |
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| Titre de la conférence : |
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Endoscopic Microscopy VI, Nonlinear Endomicroscopy |
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| Date de la conférence : |
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23/01/2011 |
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| Date de la conférence (fin) : |
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23/01/2011 |
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| Ville : |
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San franscisco - Californie |
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| Pays : |
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États-Unis |
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