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Exclusion processes: short range correlations induced by adhesion and contact interactions
Ascolani G., Badoual M., Deroulers C.
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Physique/Matière Condensée/Mécanique statistique
Sciences du Vivant/Biologie cellulaire/Interactions cellulaires
Exclusion processes: short range correlations induced by adhesion and contact interactions
Gianluca Ascolani ()1, Mathilde Badoual ()1, Christophe Deroulers (, http://www.imnc.in2p3.fr/pagesperso/deroulers/)1
1 :  IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
CNRS : UMR8165 – IN2P3 – Université Paris XI - Paris Sud – Université Paris VII - Paris Diderot
BATIMENT 104 15 Rue Georges Clémenceau 91406 ORSAY CEDEX
We analyze the out-of-equilibrium behavior of exclusion processes where agents interact with their nearest neighbors, and we study the short-range correlations which develop because of the exclusion and other contact interactions. The form of interactions we focus on, including adhesion and contact-preserving interactions, is especially relevant for migration processes of living cells. We show the local agent density and nearest-neighbor two-point correlations resulting from simulations on two dimensional lattices in the transient regime where agents invade an initially empty space from a source and in the stationary regime between a source and a sink. We compare the results of simulations with the corresponding quantities derived from the master equation of the exclusion processes, and in both cases, we show that, during the invasion of space by agents, a wave of correlations travels with velocity v(t) ∼ t^(−1/2). The relative placement of this wave to the agent density front and the time dependence of its height may be used to discriminate between different forms of contact interactions or to quantitatively estimate the intensity of interactions. We discuss, in the stationary density profile between a full and an empty reservoir of agents, the presence of a discontinuity close to the empty reservoir. Then, we develop a method for deriving approximate hydrodynamic limits of the processes. From the resulting systems of partial differential equations, we recover the self-similar behavior of the agent density and correlations during space invasion.

cell migration – exclusion process – adhesion – correlations – migration assay – cell-cell interactions
87.18.Gh, 87.10.Ed, 05.10.-a, 87.10.Hk, 87.17.Aa, 87.18.Hf, 89.75.Da, 89.75.-k

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