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PIXSIC: a Pixellated Radiosensitive Intracerebral Beta Microprobe Allowing the Kinetics Measurements of Radiotracer on Awake and Fully Freely Moving Small Animals
Godart J., Clemens J., Delpierre P., Dinskespiler B., Pangaud P. et al
World Molecular Imaging Congress 2008, Nice : France (2008) - http://hal.in2p3.fr/in2p3-00322279
Physique/Physique/Instrumentations et Détecteurs
PIXSIC: a Pixellated Radiosensitive Intracerebral Beta Microprobe Allowing the Kinetics Measurements of Radiotracer on Awake and Fully Freely Moving Small Animals
J. Godart1, J. Clemens2, P. Delpierre2, B. Dinskespiler2, P. Pangaud2, L. Pinot1, S. Godiot2, H. Gurden1, F. Lefebvre1, R. Mastrippolito1, M. Menouni2, F. Pain1, C. Morel2, P. Laniece1
1 :  IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
CNRS : UMR8165 – IN2P3 – Université Paris XI - Paris Sud – Université Paris VII - Paris Diderot
BATIMENT 104 15 Rue Georges Clémenceau 91406 ORSAY CEDEX
France
2 :  CPPM - Centre de Physique des Particules de Marseille
http://marwww.in2p3.fr/
CNRS : UMR7346 – IN2P3 – Université de la Méditerranée - Aix-Marseille II
163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09
France
The emergence of new animal models that mimic human disorders enables new fundamental and therapeutical approaches of these diseases. The increasing number of studies on animal models implies the development of new imaging tools adapted to the particular constraints of small animal studies. To that aim, the past few years have seen the development of numerous high resolution PET systems having a sensitivity and a spatial resolution well suited to the small animal imaging. Nevertheless, although these systems have already and extensively demonstrated their interest in the biomedical imaging field, they suffer from a few drawbacks (low temporal resolution, animal immobilization, high cost) that have stimulated the development of complementary approaches. In that particular context, our objective is to develop a beta radiosensitive probe surgically implantable in an animal brain that can measure autonomously the variation of injected radioactivity in a small tissue volume (typically a few mm3) on awake and freely moving animals. To reach that aim, the detector and its acquisition system must be entirely worn by the animal without wires except on the animal itself. This means to design a beta sensitive detector of very small size based on a technology that allows to produce a numerical signal compatible with the use of a telemetric system. This also means to develop a detector compact enough to be fixed on the rodent head without altering the animal movements. Moreover, the whole system must be allow the implantation of at least two probes in order to be able to measure on same animal, specific and non-specific binding rates of a radiotracer. Theoretical and experimental investigations carried out to demonstrate the feasibility of such a detector will be presented. On this basis, first architecture of the detector based on pixellated Si sensor technology will be proposed and detailed.

Communications sans actes
2008

World Molecular Imaging Congress 2008
Poster
Nice
France
10/09/2008
13/09/2008
J. Godart