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New concept of a submillimetric pixellated Silicon detector for intracerebral application
Benoit M., Märk J., Weiss P., Benoit D., Clemens J.C. et al
Nuclear Instruments and Methods in Physics Research Research: Accelerators, Spectrometers, Detectors and Associated Equipment 659 (2011) 499-503 - http://hal.in2p3.fr/in2p3-00618519
Sciences du Vivant/Ingénierie biomédicale
Sciences de l'ingénieur/Micro et nanotechnologies/Microélectronique
New concept of a submillimetric pixellated Silicon detector for intracerebral application
M. Benoit1, J. Märk2, P. Weiss2, D. Benoit3, J.C. Clemens2, D. Fougeron2, B. Janvier3, M. Jevaud2, S. Karkar2, M. Menouni2, F. Pain3, L. Pinot3, C. Morel2, P. Laniece ()3
1 :  LAL - Laboratoire de l'Accélérateur Linéaire
http://www.lal.in2p3.fr/
CNRS : UMR8607 – IN2P3 – Université Paris XI - Paris Sud
Centre Scientifique d'Orsay B.P. 34 91898 ORSAY Cedex
France
2 :  CPPM - Centre de Physique des Particules de Marseille
http://marwww.in2p3.fr/
CNRS : UMR7346 – IN2P3 – Université de la Méditerranée - Aix-Marseille II
163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09
France
3 :  IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie
CNRS : UMR8165 – IN2P3 – Université Paris XI - Paris Sud – Université Paris VII - Paris Diderot
BATIMENT 104 15 Rue Georges Clémenceau 91406 ORSAY CEDEX
France
A new beta+ radiosensitive microprobe implantable in rodent brain dedicated to in vivo and autonomous measurements of local time activity curves of beta radiotracers in a volume of brain tissue of a few mm3 has been developed recently. This project expands the concept of the previously designed beta microprobe, which has been validated extensively in neurobiological experiments performed on anesthetized animals. Due to its limitations considering recordings on awake and freely moving animals, we have proposed to develop a wireless setup that can be worn by an animal without constraining its movements. To that aim, we have chosen a highly beta sensitive Silicon-based detector to devise a compact pixellated probe. Miniaturized wireless electronics is used to read-out and transfer the measurement data. Initial Monte-Carlo simulations showed that high resistive Silicon pixels are appropriate for this purpose, with their dimensions to be adapted to our specific signals. More precisely, we demonstrated that 200 μm thick pixels with an area of 200 μm×500 μm are optimized in terms of beta+sensitivity versus relative transparency to the gamma background. Based on this theoretical study, we now present the development of the novel sensor, including the system simulations with technology computer-assisted design (TCAD) to investigate specific configurations of guard rings and their potential to increase the electrical isolation and stabilization of the pixel, as well as the corresponding physical tests to validate the particular geometries of this new sensor.

Articles dans des revues avec comité de lecture
2011
Nuclear Instruments and Methods in Physics Research Research: Accelerators, Spectrometers, Detectors and Associated Equipment
659
499-503
2011 Published by Elsevier B.V.

Intracerebral probe – PET imaging – Silicon pixel detectors – Small animal imaging