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Nuclear Instruments and Methods in Physics Research Research Section B: Beam Interactions with Materials and Atoms 181, 1-4 (2001) 475-479
In-air scanning transmission ion microscopy of cultured cancer cells
Richard Ortega1, Guillaume Devès1, Philippe Moretto2

Scanning transmission ion microscopy (STIM) imaging of living cultured cells has been carried out using a proton external-beam with the nuclear microprobe of Bordeaux-Gradignan. STIM could be performed in air atmosphere after passage of a focused proton beam through a 150 nm thick silicon nitride window. Energy loss STIM images were obtained with a spatial resolution in the micrometer range and enabled the identification of sub-cellular ultrastructures.
1 :  CNAB - Chimie Nucléaire Analytique et Bio-environnementale
2 :  CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan
Physique/Physique/Instrumentations et Détecteurs
Cell imaging – Living cells – Nuclear microprobe – STIM