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Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods
Lao J., Nedelec J.-M., Moretto P., Jallot E.
Nuclear Instruments and Methods in Physics Research Research Section B: Beam Interactions with Materials and Atoms 261 (2007) 488-493 - http://hal.archives-ouvertes.fr/hal-00174449
Chimie/Matériaux
Physique/Matière Condensée/Science des matériaux
Physique/Physique/Biophysique
Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods
J. Lao1, Jean-Marie Nedelec ()2, P. Moretto3, Edouard Jallot ()1
1 :  LPC - Laboratoire de Physique Corpusculaire [Clermont-Ferrand]
http://clrwww.in2p3.fr/
CNRS : UMR6533 – IN2P3 – Université Blaise Pascal - Clermont-Ferrand II
Campus des Cézeaux 24, avenue des Landais BP 80026 63171 Aubière Cedex
France
2 :  LMI - Laboratoire des Matériaux Inorganiques
CNRS : UMR6002 – Université Blaise Pascal - Clermont-Ferrand II – Clermont Université – Ecole Nationale Supérieure de Chimie de Clermont-Ferrand
24 Avenue des Landais 63177 AUBIERE CEDEX
France
3 :  CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan
http://www.cenbg.in2p3.fr/
CNRS : UMR5797 – IN2P3 – Université Sciences et Technologies - Bordeaux I
Chemin du Solarium - BP 120 - 33175 Gradignan Cedex
France
It is proposed in this study to observe the influence of P2O5 on the formation of the apatite-like layer in a bioactive glass via a complete PIXE characterization. A glass in the SiO2-CaO-P2O5 ternary system was elaborated by sol-gel processing. Glass samples were soaked in biological fluids for periods up to 10 days. The surface changes were characterized using Particle Induced X-ray Emission (PIXE) associated to Rutherford Backscattering Spectroscopy (RBS), which are efficient methods for multielemental analysis. Elemental maps of major and trace elements were obtained at a micrometer scale and revealed the bone bonding ability of the material. The formation of a calcium phosphate-rich layer containing magnesium occurs after a few days of interaction. We demonstrate that the presence of phosphorus in the material has an impact on the development and the formation rate of the bone-like apatite layer. Indeed, the Ca/P atomic ratio at the glass/biological fluids interface is closer to the nominal value of pure apatite compared to P2O5 free glasses. It would permit, in vivo, an improved chemical bond between the biomaterials and bone.
Anglais

Nuclear Instruments and Methods in Physics Research Research Section B: Beam Interactions with Materials and Atoms
internationale
Articles dans des revues avec comité de lecture
2007
261
488-493

PIXE-RBS methods – biomaterials – bioactive glass – sol-gel
PACS: 68.08.–p; 81.05.Kf; 81.20.Fw; 82.80.Ej; 82.80.Yc; 87.64.Gb; 87.68.+z
presented at CAARI 2006:19th International Conference on the Application of Accelerators in Research and Industry, Forth Worth, Etats Unis, 20-25 Aug 2006, 11 pp, 4 figures, submitted to NIMB - PNAB, présenté par J. Lao, à paraître dans NIMB

ANR PNANO Bioverres
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