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Co-registration of Stereotactic MRI and Isofieldlines During Deep Brain Stimulation
Hemm S., Mennessier G., Vayssière N., Cif L., Coubes P.
Brain Researchearch 68, 1-2 (2005) 59 - 61 - http://hal.archives-ouvertes.fr/hal-00271686
Sciences du Vivant/Neurosciences/Neurobiologie
Co-registration of Stereotactic MRI and Isofieldlines During Deep Brain Stimulation
S. Hemm, Gerard Mennessier ()1, N. Vayssière, L. Cif, P. Coubes
1 :  LPTA - Laboratoire de Physique Théorique et Astroparticules
CNRS : UMR5207 – IN2P3 – Université Montpellier II - Sciences et techniques
Bât 13- 1er Et. - CC 070 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5
Object: The parameter adjustment process during deep brain stimulation (DBS) for dystonia remains time consuming and based on clinical observation alone. The aim was to correlate the electric field with the GPi anatomy tobe able to study the stimulated volume. Methods: We developed a computer-assisted method (model) for visualizing electric field in reference to the stereotactic space. Electric field values were correlated with the GPi anatomy (stereotactic Magnetic Resonance Imaging) in one reference patient. Results: Using this methodology it becomes possible to correlate the electric field distributions for patient specific parameters with the anatomical information. The application to one patient showed that the 0.1 V/mm isofieldline fits best with the lateral GPi borders at the level of the stimulated contacts. Conclusions: The electric field is a crucial parameter as it is assumed to be responsible for triggering action potentials. Electric field visualisation allows the calculation of the stimulated volume for a given isoline. Its application to our whole patient population might help in determining a threshold for obtaining a therapeutic effect, to date unknown, and consequently in optimizing the parameter setting in each patient.

Brain Researchearch
non spécifiée
Articles dans des revues avec comité de lecture
59 - 61

Proceedings of the 14th and 15th Meetings of the European Network for CNS Transplantation and Repair (NECTAR)
05-077; 05-077