version française rss feed
HAL : hal-00486366, version 1

Fiche concise  Récupérer au format
Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension
Habold C., Momken I., Ouadi A., Bekaert V., Brasse D.
Journal of Bone and Mineral Metabolism 29 (2011) 15-22 - http://hal.archives-ouvertes.fr/hal-00486366
Sciences du Vivant/Biodiversité/Evolution
Sciences de l'environnement
Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension
Caroline Habold1, Iman Momken2, Ali Ouadi1, Virgile Bekaert1, David Brasse1
1 :  DRS-IPHC - Département Recherches Subatomiques
CNRS : UMR7178 – IN2P3 – Université de Strasbourg
23 rue du Loess - BP28 67037 Strasbourg cedex 2
2 :  DEPE-IPHC - Département Ecologie, Physiologie et Ethologie
CNRS : UMR7178 – Université de Strasbourg
23, rue Becquerel 67087 Strasbourg Cedex 2
Physical inactivity during space flight or prolonged bed rest causes rapid and marked loss of bone mass in humans. Resveratrol, a red wine polyphenol that is currently under study for its therapeutic antioxidant properties, has been shown to significantly modulate biomarkers of bone metabolism, i.e., to promote osteoblast differentiation and to prevent bone loss induced by estrogen deficiency. However, there is no direct evidence supporting its inhibitory effect toward bone loss during physical inactivity. In the present study, effects of resveratrol on bone mineral density (BMD), bone mineral content, and bone structure were examined in the femora and tibiae of tail-suspended and unsuspended rats using X-ray micro-computed tomography (micro-CT). Rats were treated with 400 mg/kg/day of resveratrol for 45 days and half of them were suspended during the last 2 weeks of treatment. Suspension caused a decrease in tibial and femoral BMD and deterioration of trabecular and cortical bone. Bone deterioration during suspension was paralleled by increased bone marrow area, which could be caused by an increase in stromal cells with osteoclastogenic potential or in adipocytes. Resveratrol had a preventive effect against bone loss induced by hindlimb immobilization. In particular, trabecular bone in the proximal tibial metaphysis was totally preserved in rats treated with resveratrol before tail-suspension.

Journal of Bone and Mineral Metabolism (J Bone Miner Metab)
Publisher Springer Verlag (Germany)
ISSN 0914-8779 (eISSN : 1435-5604)
Articles dans des revues avec comité de lecture

Bone mineral density – Trabecular bone – X-ray micro-computed tomography