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(Exposure to fine air particles and occurrence of allergic diseases: results of ISAAC-France phase 2).
Annesi-Maesano I., Caillaud D., Lavaud F., Moreau D., Le Moullec Y. et al
Archives de Pédiatrie 16, 3 (2009) 299-305 - http://hal.upmc.fr/hal-00595449
Sciences du Vivant/Santé publique et épidémiologie
[Exposure to fine air particles and occurrence of allergic diseases: results of ISAAC-France phase 2].
I. Annesi-Maesano ()1, D. Caillaud, F. Lavaud2, D. Moreau3, Y. Le Moullec4, A. Taytard, G. Pauli, D. Charpin
1 :  ESIM - Epidémiologie des maladies infectieuses et modélisation
INSERM : U707 – Université Pierre et Marie Curie (UPMC) - Paris VI
Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12
2 :  IPNO - Institut de Physique Nucléaire d'Orsay
CNRS : UMR8608 – IN2P3 – Université Paris XI - Paris Sud
IPN - 15, rue Georges Clemenceau - 91406 ORSAY CEDEX
3 :  Service de réanimation médicale
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Saint-Louis – Université Paris VII - Paris Diderot
1 rue Claude Vellefaux 75011 Paris
4 :  LSGC - Laboratoire des Sciences du Génie Chimique
CNRS : UPR6811
1, rue Grandville BP 20451 54001 NANCY cedex
To evaluate whether fine air particles could be involved in the occurrence of atopy and allergic diseases, we performed a cross-sectional epidemiological survey involving primary schoolchildren living in six French towns with contrasted air pollution levels. Air pollution was measured during a week in the school yards and by standard air monitoring networks. Children get an examination in school looking for atopic dermatitis and bronchial hyperresponsiveness assessed by a standardized run test. Besides, parents or guardians provided past medical history and environmental data, especially on passive smoking. Overall, 5,338 children, aged 10.4 (+/-0.7) years, coming from 108 different schools and 401 different classes were included in the survey. Taking into account potential confounders, high exposure to proximity PM(2.5) was linked to a higher point prevalence of atopic dermatitis and hyperresponsiveness, to a higher cumulative prevalence of allergic asthma and a higher sensitization rate to common indoor allergens. Thus, these data suggest that chronic exposure to urban fine particles could be a risk factor for atopy, hyperresponsiveness and asthma.
Pôle 4 vie et sante

Annesi-Maesano I, Caillaud D, Lavaud F, Moreau D, Le Moullec Y, Taytard A, Pauli G, Charpin D.

Archives de Pédiatrie (Arch Pediatr)
Publisher Elsevier
ISSN 0929-693X 
Articles dans des revues avec comité de lecture

Air Pollution – Asthma – Bronchial Hyperreactivity – Child – Cross-Sectional Studies – Dermatitis – Atopic – Environmental Exposure – Female – France – Health Surveys – Humans – Male – Particle Size – Population Surveillance