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Leukocyte count and bronchial hyperresponsiveness.
Annesi I., Kauffmann F., Oryszczyn M.P., Neukirch F., Orvoen-Frija E. et al
Journal of Allergy and Clinical Immunology 82, 6 (1988) 1006-11 - http://hal.upmc.fr/hal-00596546
Sciences du Vivant/Santé publique et épidémiologie
Leukocyte count and bronchial hyperresponsiveness.
I. Annesi ()1, F. Kauffmann2, M. P. Oryszczyn, F. Neukirch, E. Orvoen-Frija, J. Lellouch3
1 :  ESIM - Epidémiologie des maladies infectieuses et modélisation
http://www.u707.jussieu.fr
INSERM : U707 – Université Pierre et Marie Curie (UPMC) - Paris VI
Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12
France
2 :  GREYC - Groupe de Recherche en Informatique, Image, Automatique et Instrumentation de Caen
http://www.greyc.fr
CNRS : UMR6072 – Université de Caen Basse-Normandie – Ecole Nationale Supérieure d'Ingénieurs de Caen
Boulevard du Maréchal Juin - 14050 CAEN Cedex
France
3 :  LPNHE - Laboratoire de Physique Nucléaire et de Hautes Énergies
http://www-lpnhep.in2p3.fr
CNRS : UMR7585 – IN2P3 – Université Pierre et Marie Curie (UPMC) - Paris VI – Université Paris VII - Paris Diderot
Barre 12-22, 1er étage 4 Place Jussieu 75252 Paris Cedex 05
France
The relationship of total and differential blood leukocyte counts with bronchial methacholine response was studied in a population-based sample of 324 men. Geometric mean total leukocyte counts were significantly higher in reactors (6567 cells/mm3) than in nonreactors (5732 cells/mm3; p = 0.003). After adjusting for smoking habits, a factor contributing to both an elevation in peripheral leukocyte count and an increased level of airway responsiveness, reactor status remained significantly associated with leukocyte count. This association also persisted after controlling, with a logistic model, for atopy and common cold (marker of infection) and after excluding men with a history of asthma, chronic bronchitis, or low FEV1. Study of the differential leukocyte counts has shown that an increase was present for almost every type of leukocyte, and particularly evident for neutrophils. Whether these findings reflect an association between bronchial hyperresponsiveness and cellular inflammation needs more investigation.
Anglais
Pôle 4 vie et sante

Journal of Allergy and Clinical Immunology (J Allergy Clin Immunol)
Publisher Elsevier
ISSN 0091-6749 
internationale
Articles dans des revues avec comité de lecture
12/1988
82
6
1006-11

Adult – Asthma – Bronchial Provocation Tests – Common Cold – Humans – Hypersensitivity – Immediate – Leukocyte Count – Male – Methacholine Chloride – Methacholine Compounds – Middle Aged – Respiratory Hypersensitivity – Risk Factors – Smoking