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Relation of perceived nasal and bronchial hyperresponsiveness to FEV1, basophil counts, and methacholine response.
Kauffmann F., Neukirch F., Annesi I., Korobaeff M., Doré M.F. et al
Thorax 43, 6 (1988) 456-61 - http://hal.upmc.fr/hal-00596552
Sciences du Vivant/Santé publique et épidémiologie
Relation of perceived nasal and bronchial hyperresponsiveness to FEV1, basophil counts, and methacholine response.
F. Kauffmann1, F. Neukirch, I. Annesi ()2, M. Korobaeff, M. F. Doré, J. Lellouch3
1 :  GREYC - Groupe de Recherche en Informatique, Image, Automatique et Instrumentation de Caen
http://www.greyc.fr
CNRS : UMR6072 – Université de Caen Basse-Normandie – Ecole Nationale Supérieure d'Ingénieurs de Caen
Boulevard du Maréchal Juin - 14050 CAEN Cedex
France
2 :  ESIM - Epidémiologie des maladies infectieuses et modélisation
http://www.u707.jussieu.fr
INSERM : U707 – Université Pierre et Marie Curie (UPMC) - Paris VI
Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12
France
3 :  LPNHE - Laboratoire de Physique Nucléaire et de Hautes Énergies
http://www-lpnhep.in2p3.fr
CNRS : UMR7585 – IN2P3 – Université Pierre et Marie Curie (UPMC) - Paris VI – Université Paris VII - Paris Diderot
Barre 12-22, 1er étage 4 Place Jussieu 75252 Paris Cedex 05
France
Perceived nasal and bronchial hyperresponsiveness to tobacco smoke and cold air were assessed in 912 working men in the Paris area. Baseline lung function measurements and peripheral leucocyte counts with standard differential counts were performed. At least one perceived nasal or bronchial hyperresponsiveness symptom was reported by 15.7%. Current smoking was significantly less frequent among those with cough induced by tobacco smoke. Rhinitis induced by cold air was associated with lower FEV1 (p less than 0.01) and the association remained after adjustment for smoking, asthma, and wheezing (p = 0.06). Symptoms induced by cold air were related to circulating basophils. Neither perceived nasal nor perceived bronchial hyperresponsiveness was significantly related to the airway response to methacholine in a sample of the group (n = 324) surveyed again five years later. The result suggest that the symptom of rhinitis provoked by cold air is a possible "new" risk factor or marker for chronic airflow limitation.
Anglais
Pôle 4 vie et sante

Kauffmann F , Neukirch F , Annesi I , M Korobaeff , MF Doré , Lellouch J .

Thorax (Thorax)
Publisher BMJ Publishing Group
ISSN 0040-6376 
internationale
Articles dans des revues avec comité de lecture
06/1988
43
6
456-61

Adult – Airway Resistance – Asthma – Basophils – Bronchi – Bronchial Provocation Tests – Cold Temperature – Forced Expiratory Volume – Humans – Leukocyte Count – Male – Methacholine Compounds – Middle Aged – Nasal Mucosa – Nasal Provocation Tests – Plants – Toxic – Smoke – Tobacco