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Icosahedral viruses: physical principles of capsid structure classification, self-assembly and maturation
Lorman V.
Physics and Mechanics of Biological Systems, Paris : France (2010) - http://hal.archives-ouvertes.fr/hal-00654104
Physique/Physique/Biophysique
Icosahedral viruses: physical principles of capsid structure classification, self-assembly and maturation
Vladimir Lorman ()1
1 :  LPTA - Laboratoire de Physique Théorique et Astroparticules
http://www.lpta.in2p3.fr/
CNRS : UMR5207 – IN2P3 – Université Montpellier II - Sciences et techniques
Bât 13- 1er Et. - CC 070 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5
France
In the present work we generalize Landau theory of crystallization to explain and to classify the capsid structures of small viruses with spherical topology and icosahedral symmetry. We develop an explicit method which predicts the positions of centers of mass for the proteins constituting viral capsid shell. The peculiarities of the assembly thermodynamics are also discussed. Finally, we show the relation between the protein density distributions obtained and the infectivity properties of several human viruses.
Anglais
16/12/2010

internationale
Conférences invitées
16/12/2010

Physics and Mechanics of Biological Systems
16/12/2010
17/12/2010
Paris
France

physics – mechanics – biological systems – cell – intracellular assemblies – tissus
L2C:10-062