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Influence of mesostructuration on the reactivity of bioactive glasses in biological medium: a PIXE-RBS study
Soulié J., Lao J., Jallot E., Nedelec J.-M.
Journal of Materials Chemistry 22, 38 (2012) 20680 - 20688 - http://hal.archives-ouvertes.fr/hal-00731072
Chimie/Matériaux
Influence of mesostructuration on the reactivity of bioactive glasses in biological medium: a PIXE-RBS study
Jeremy Soulié1, 2, Johnatan Lao1, Edouard Jallot1, Jean-Marie Nedelec (, http://www.univ-bpclermont.fr/LABOS/lmi)2
1 :  LPC-CLERMONT - Laboratoire de Physique Corpusculaire de Clermont-Ferrand
http://clrwww.in2p3.fr/
CNRS : UMR6533 – IN2P3 – Université Blaise Pascal - Clermont-Ferrand II
Campus des Cézeaux 24, avenue des Landais BP 80026 63171 Aubière Cedex
France
2 :  ICCF - Institut de Chimie de Clermont-Ferrand
Université Blaise Pascal - Clermont-Ferrand II – CNRS : UMR6296 – Ecole Nationale Supérieure de Chimie de Clermont-Ferrand
24 Avenue des Landais, 63177 Aubière Cedex
France
Building mesostructured biomaterials is a challenging and exciting task that has attracted much attention because of their use as drug carriers or drug delivery systems. In the case of bioactive materials, the mesostructuration can also deeply impact their physico-chemical properties and the reactivity. In this study, we show how highly ordered mesoporosity influence the early steps of biomineralization process and the reactivity in binary (SiO2-CaO) and ternary (SiO2-CaO-P2O5) bioactive glasses. Conventional porous sol-gel glasses were synthesized using a classical route, while mesostructured glasses were elaborated using a non-ionic surfactant. Textural properties of these materials have been characterized. The in vitro biomineralization process was followed, using Particle Induced X-ray Emission (PIXE) associated to Rutherford Backscattering, Spectrometry (RBS), which are efficient methods for a highly sensitive multi-elemental analysis. Elemental maps of silicon, calcium and phosphorus were obtained at a micrometer scale and revealed for the first time a bulk reactivity for mesostructured glasses. This is a major advantage over conventional glasses, for which the first steps of biomineralization are limited to the periphery of the material. Their enhanced bioactivity combined with their possible use as drug-delivery systems make them promising candidates for bone regeneration.
Anglais
2012

Journal of Materials Chemistry
Publisher Royal Society of Chemistry
ISSN 0959-9428 (eISSN : 1364-5501)
internationale
Articles dans des revues avec comité de lecture
15/08/2012
22
38
20680 - 20688

bioglasses – mesoporous – sol-gel – mesostructured

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