version française rss feed
HAL : in2p3-00321614, version 1

Fiche détaillée  Récupérer au format
International Journal of Radiation Oncology Biology Physics 71 (2008) 635-642
Radiobiologic Parameters and Local Effect Model Predictions for Head-and-Neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions
M. Beuve1, 2, G. Alphonse3, 4, M. Maalouf3, A. Colliaux1, 2, P. Battiston-Montagne3, P. Jalade4, E. Balanzat5, 6, A. Demeyer1, 2, M. Bajard1, 2, C. Rodriguez-Lafrasse3, 4

To establish the radiobiologic parameters of head-and-neck squamous cell carcinomas (HNSCC) in response to ion irradiation with various linear energy transfer (LET) values and to evaluate the relevance of the local effect model (LEM) in HNSCC. Methods and Materials Cell survival curves were established in radiosensitive SCC61 and radioresistant SQ20B cell lines irradiated with [33.6 and 184 keV/n] carbon, [302 keV/n] argon, and X-rays. The results of ion experiments were confronted to LEM predictions. Results The relative biologic efficiency ranged from 1.5 to 4.2 for SCC61 and 2.1 to 2.8 for SQ20B cells. Fixing an arbitrary D0 parameter, which characterized survival to X-ray at high doses (>10 Gy), gave unsatisfying LEM predictions for both cell lines. For D0 = 10 Gy, the error on survival fraction at 2 Gy amounted to a factor of 10 for [184 keV/n] carbon in SCC61 cells. We showed that the slope (smax) of the survival curve at high doses was much more reliable than D0. Fitting smax to 2.5 Gy−1 gave better predictions for both cell lines. Nevertheless, LEM could not predict the responses to fast and slow ions with the same accuracy. Conclusions The LEM could predict the main trends of these experimental data with correct orders of magnitude while smax was optimized. Thus the efficiency of carbon ions cannot be simply extracted from the clinical response of a patient to X-rays. LEM should help to optimize planning for hadrontherapy if a set of experimental data is available for high-LET radiations in various types of tumors.
1 :  IPNL - Institut de Physique Nucléaire de Lyon
2 :  LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
3 :  EA3738 - Ciblage thérapeutique en Oncologie
4 :  HCL - Hospices Civils de Lyon / Centre hospitalier Lyon Sud
5 :  CIRIL (GANIL) - Centre Interdisciplinaire de Recherche Ions Lasers
6 :  CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
Physique/Physique/Physique Médicale

Sciences du Vivant/Cancer
High-LET ion – Carbon irradiation – Argon irradiation – Local effect model – Head-and-neck squamous cell carcinoma
Liste des fichiers attachés à ce document : 
in2p3-00321614.pdf(272.9 KB)