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| HAL : in2p3-00355163, version 1 |
| DOI : 10.1080/17435390802538508 |
| Fiche détaillée |  Récupérer au format |
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| Nanotoxicology 2 (2008) 218-231 |
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| Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study |
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| E. GontierM. YnsaT. BiacuteroacuteJ. HunyadiB. KissK. GaacutespaacuterT. PinheiroJ. SilvaP. FilipeJ. StachuraW. DabrosT. ReinertP. Moretto1T. ButzJ. Surlegraveve-Bazeille |
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| (04/12/2008) |
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| We report on a comparative study by Transmission Electron Microscopy (HRTEM) and Scanning Transmission Ion Microscopy (STIM) combined with Rutherford Backscattering Spectrometry (RBS) and Particle Induced X-Ray Emission (PIXE) on ultra-thin and thin cross-sections, respectively, of various skin samples (porcine skin, healthy human skin, human skin grafted on a severe combined immuno-deficient mouse model) to which we applied topically various formulations containing titanium dioxide (TiO2) nanoparticles with primary particle sizes in the range from 20-100 nm. Whereas the HRTEM and STIM/PIXE images reveal clear differences - mainly related to the different thickness of the cross-sections - they unambiguously show that penetration of TiO2 nanoparticles is restricted to the topmost 3-5 corneocyte layers of the stratum corneum (SC). |
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| 1 : | CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan |
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| Thème(s) | : | Sciences du Vivant/Toxicologie Physique/Physique/Biophysique Sciences du Vivant/Ecologie, Environnement |
| in2p3-00355163, version 1 | |
| http://hal.in2p3.fr/in2p3-00355163 | |
| oai:hal.in2p3.fr:in2p3-00355163 | |
| Contributeur : Virginie Mas | |
| Déposé pour le compte de : | |
| Soumis le : Jeudi 22 Janvier 2009, 16:07:26 | |
| Dernière modification le : Jeudi 22 Janvier 2009, 16:13:12 | |
