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Malaria Journal 8 (2009) 88
WISDOM-II: Screening against multiple targets implicated in malaria using computational grid infrastructures
V. Kasam1, 2, J. Salzemann1, M. Botha, A. Dacosta1, G. Degliesposti, R. Isea, D. Kim, A. Maass, C. Kenyon, G. Rastelli, M. Hofmann-Apitius, V. Breton1
WISDOM Collaboration(s)
(2009)

Despite continuous efforts of the international community to reduce the impact of malaria on developing countries, no significant progress has been made in the recent years and the discovery of new drugs is more than ever needed. Out of the many proteins involved in the metabolic activities of the Plasmodium parasite, some are promising targets to carry out rational drug discovery. Motivation Recent years have witnessed the emergence of grids, which are highly distributed computing infrastructures particularly well fitted for embarrassingly parallel computations like docking. In 2005, a first attempt at using grids for large-scale virtual screening focused on plasmepsins and ended up in the identification of previously unknown scaffolds, which were confirmed in vitro to be active plasmepsin inhibitors. Following this success, a second deployment took place in the fall of 2006 focussing on one well known target, dihydrofolate reductase (DHFR), and on a new promising one, glutathione-S-transferase.
1 :  LPC-CLERMONT - Laboratoire de Physique Corpusculaire de Clermont-Ferrand
2 :  SCAI - Department of Bioinformatics
Informatique/Bio-informatique

Sciences du Vivant/Bio-Informatique, Biologie Systémique
WISDOM – malaria – grid