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Journal of the Royal Society Interface Focus 1, 3 (2011) 349--364
euHeart: Personalized and integrated cardiac care using patient-specific cardiovascular modelling
Nic Smith1, 2, A. De Vecchi1, M. McCormick2, 3, D. Nordsletten1, Oscar Camara4, 5, Alejandro Frangi4, 5, 6, 7, Hervé Delingette8, Maxime Sermesant8, Jatin Relan8, Nicholas Ayache8, M.W. Krueger9, W. Schulze9, Rod Hose10, I. Valverde1, P. Beerbaum1, C. Staicu10, M. Siebes11, J. Spaan11, Peter Hunter12, J. Weese13, H. Lehmann14, Dominique Chapelle15, Reza Razavi16, 17

The loss of cardiac pump function accounts for a significant increase in both mortality and morbidity in Western society, where there is currently a one in four lifetime risk, and costs associated with acute and long-term hospital treatments are accelerating. The significance of cardiac disease has motivated the application of state-of-the-art clinical imaging techniques and functional signal analysis to aid diagnosis and clinical planning. Measurements of cardiac function currently provide high-resolution datasets for characterizing cardiac patients. However, the clinical practice of using population-based metrics derived from separate image or signal-based datasets often indicates contradictory treatments plans owing to inter-individual variability in pathophysiology. To address this issue, the goal of our work, demonstrated in this study through four specific clinical applications, is to integrate multiple types of functional data into a consistent framework using multi-scale computational modelling.
1 :  Imaging Sciences and Biomedical Engineering Division [London]
2 :  OUCL - Computing Laboratory
3 :  IPNO - Institut de Physique Nucléaire d'Orsay
4 :  CISTIB - Center for Computational Imaging and Simulation Technologies in Biomedicine
5 :  CIBER-BBN - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
6 :  ICREA - Institució Catalana de Recerca i Estudis Avançats [Barcelona]
7 :  Institute of Simulation and Graphics [Magdeburg]
8 :  INRIA Sophia Antipolis - ASCLEPIOS
9 :  Institute of Biomedical Engineering [Karlsruhe]
10 :  Department of Cardiovascular Science [Sheffield]
11 :  AMC - Academic Medical Center Amsterdam
12 :  Auckland Bioengineering Institute
13 :  Philips Research Laboratories [Eindhoven]
14 :  Philips Research [Nederlands]
15 :  INRIA Rocquencourt - MACS
16 :  Division of Imaging Sciences
17 :  NIHR Biomedical Research Centre [London]
Informatique/Imagerie médicale

Informatique/Modélisation et simulation

Sciences du Vivant/Ingénierie biomédicale/Imagerie

Sciences de l'ingénieur/Traitement du signal et de l'image

Informatique/Traitement du signal et de l'image