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Inter-Model Consistency and Complementarity: Learning from ex-vivo Imaging and Electrophysiological Data towards an Integrated Understanding of Cardiac Physiology
Camara O., Sermesant M., Lamata P., Wang L., Pop M. et al
Progress in Biophysics and Molecular Biology 107, 1 (2011) 122-133 - http://hal.inria.fr/inria-00616197
Informatique/Imagerie médicale
Informatique/Modélisation et simulation
Sciences du Vivant/Ingénierie biomédicale/Imagerie
Sciences de l'ingénieur/Traitement du signal et de l'image
Informatique/Traitement du signal et de l'image
Inter-Model Consistency and Complementarity: Learning from ex-vivo Imaging and Electrophysiological Data towards an Integrated Understanding of Cardiac Physiology
Oscar Camara1, 2, Maxime Sermesant ()3, P. Lamata4, 5, L. Wang6, 7, 8, 9, Mihaela Pop10, Jatin Relan3, M. De Craene1, 2, Hervé Delingette ()3, H. Liu11, 12, 13, S. Niederer4, A. Pashaei1, 2, G. Plank14, D. Romero1, 2, R. Sebastian15, Ken C.L. Wong3, H. Zhang16, 17, 18, 19, 20, Nicholas Ayache ()3, Alejandro Frangi1, 2, 21, 22, P. Shi23, Nic Smith4, 5, Graham Wright10, 24
1 :  CISTIB - Center for Computational Imaging and Simulation Technologies in Biomedicine
http://cilab2.upf.edu/index2.html
Pompeu Fabra University
Barcelone
Espagne
2 :  CIBER-BBN - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
http://www.ciber-bbn.org/
ministerio de ciencia e innovacion – Instituto de Salud Carlos III
CIBER-BBN (Salida Campus Río Ebro) C/ María de Luna, 11 Edificio CEEI 50018 Zaragoza
France
3 :  INRIA Sophia Antipolis - ASCLEPIOS
http://www-sop.inria.fr/asclepios
INRIA
2004 route des lucioles, BP93 06902 Sophia Antipolis Cedex
France
4 :  Department of Biomedical Engineering [London]
http://www.kcl.ac.uk/medicine/research/divisions/imaging/departments/biomedengineering/contact.aspx
King's College London – St Thomas Hospital
King's College London The Rayne Institute 4th Floor, Lambeth Wing St Thomas' Hospital London SE1 7EH
Royaume-Uni
5 :  Department of Computer Science [Oxford]
http://www.cs.ox.ac.uk/
University of Oxford
University of Oxford Wolfson Building Parks Road OXFORD OX1 3QD UK
Royaume-Uni
6 :  LCB - Laboratoire de chimie bactérienne
CNRS : UPR9043
31 Chemin Joseph Aiguier 13402 MARSEILLE CEDEX 20
France
7 :  LSP - Laboratoire de Spectrométrie Physique
http://www-lsp.ujf-grenoble.fr/
CNRS : UMR5588 – Université Joseph Fourier - Grenoble I
140 Avenue de la Physique - BP 87 - 38402 Saint Martin d'Hères - France
France
8 :  Biomécanique et Bioingéniérie
http://www.utc.fr/umr6600/
CNRS : UMR6600 – Université de Technologie de Compiègne
Département Génie Biologique UMR6600 Biomécanique Biomédical - BP 20529 60205 COMPIEGNE CEDEX
France
9 :  Physics - Department of Physics
http://www.physics.utoronto.ca/
University of Toronto
Department of Physics, 60 St. George St., Toronto, Ontario, M5S 1A7, Canada
Canada
10 :  Imaging Research [Sunnybrook]
http://www.sunnybrook.ca/research/?page=sri_disc_img_home
Sunnybrook Health Sciences Centre – University of Toronto
Sunnybrook Health Sciences Centre 2075 Bayview Ave., Room S6 65B Toronto, ON
Canada
11 :  SPMS - Laboratoire Structures, Propriétés et Modélisation des solides
http://www.spms.ecp.fr
CNRS : UMR8580 – Ecole Centrale Paris
Grande voie des vignes - 92295 chatenay-malabry Cedex - France
France
12 :  IEMN - Institut d'électronique, de microélectronique et de nanotechnologie
http://www.iemn.univ-lille1.fr/
CNRS : UMR8520 – Institut supérieur de l'électronique et du nunérique (ISEN) – Université Lille I - Sciences et technologies – Université de Valenciennes et du Hainaut-Cambresis
avenue Poincaré, Cité scientifique, BP 69, 59652 Villeneuve d'Ascq cedex
France
13 :  BIT - Beijing Institute of Technology
http://english.bit.edu.cn/
Beijing Institute of Technology (BIT)
5 South Zhongguancun Street, Haidian District, Beijing Postcode: 100081
Chine
14 :  Institute of Biophysics [Graz]
http://www.medunigraz.at/biophysik/
Medical University of Graz
Medical University of Graz, Harrachgasse 21/IV, 8010 Graz
Autriche
15 :  Computational Multi-Scale Physiology Lab [Valencia]
http://www.uv.es/commlab/
Universidad de Valencia
Dpt. Computer Sciences, Universitat de Valencia Bld. Farmacia, d.1.2.22. Avda. de la Universidad s/n 46950 Burjassot, Valencia, SPAIN
Espagne
16 :  ISCR - Institut des Sciences Chimiques de Rennes
http://www.scienceschimiques.univ-rennes1.fr
CNRS : UMR6226 – Université de Rennes 1 – Institut National des Sciences Appliquées [INSA] : - RENNES – Ecole Nationale Supérieure de Chimie de Rennes
Campus de Beaulieu - Bât. 10 Avenue du Général Leclerc 35042 Rennes Cedex
France
17 :  IBCP - Institut de biologie et chimie des protéines [Lyon]
http://www.ibcp.fr
CNRS : UMR5086 – Université Claude Bernard - Lyon I (UCBL)
7 Passage du Vercors 69367 LYON CEDEX 07
France
18 :  Biologie moléculaire et cellulaire de la différenciation
http://www.lyon.inserm.fr/309/index.html
INSERM : U309 – Institut Albert Bonniot – Université Joseph Fourier - Grenoble I
Domaine de La Merci 38706 LA TRONCHE CEDEX
France
19 :  CPPM - Centre de Physique des Particules de Marseille
http://marwww.in2p3.fr/
CNRS : UMR7346 – IN2P3 – Université de la Méditerranée - Aix-Marseille II
163, avenue de Luminy - Case 902 - 13288 Marseille cedex 09
France
20 :  Department of Chemistry [HKUST]
http://www-chem.ust.hk/
The Hong Kong University of Science & Technology
Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong
Hong-Kong
21 :  ICREA - Institució Catalana de Recerca i Estudis Avançats [Barcelona]
http://www.icrea.cat/web/home.aspx
ICREA – Universitat de Barcelona – Fundació Catalana per a la Recerca i la Innovació (FCRI)
Passeig Lluís Companys, 23 08010 Barcelona - Espanya
Espagne
22 :  Institute of Simulation and Graphics [Magdeburg]
http://isgwww.cs.uni-magdeburg.de/index.html.de
Otto-von-Guericke-Universität Magdeburg
Otto-von-Guericke University Institute of Simulation and Graphics POB 4120 39016 Magdeburg Germany
Allemagne
23 :  Computational Biomedicine Laboratory [Rochester]
http://www.rit.edu/
Rochester Institute of Technology
Rochester Institute of Technology 1 Lomb Memorial Drive Rochester, NY 14623-5603
États-Unis
24 :  MBP - Department of Medical Biophysics
http://medbio.utoronto.ca/index.html
University of Toronto
Department of Medical Biophysics University of Toronto Ontario Cancer Institute, Princess Margaret Hospital 610 University Avenue, Rm 7-411 Toronto, Ontario, CANADA
Canada
Computational models of the heart at various scales and levels of complexity have been independently developed, parameterised and validated using a wide range of experimental data for over four decades. However, despite remarkable progress, the lack of coordinated efforts to compare and combine these computational models has limited their impact on the numerous open questions in cardiac physiology. To address this issue, a comprehensive dataset has previously been made available to the community that contains the cardiac anatomy and fibre orientations from magnetic resonance imaging as well as epicardial transmembrane potentials from optical mapping measured on a perfused ex-vivo porcine heart. This data was used to develop and customize four models of cardiac electrophysiology with different level of details, including a personalized fast conduction Purkinje system, a maximum a posteriori estimation of the 3D distribution of transmembrane potential, the personalization of a simplified reaction-diffusion model, and a detailed biophysical model with generic conduction parameters. This study proposes the integration of these four models into a single modelling and simulation pipeline, after analyzing their common features and discrepancies. The proposed integrated pipeline demonstrates an increase prediction power of depolarization isochrones in different pacing conditions.
Anglais

Progress in Biophysics and Molecular Biology (Prog Biophys Mol Biol)
Publisher Elsevier
ISSN 0079-6107 
Articles dans des revues avec comité de lecture
2011
internationale
Elsevier
Experimental and Computational Model Interactions in Bio-Research: State of the Art
107
1
122-133

2011