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Radiation and Environmental Biophysics 49 (2010) 337-343
Real time monitoring of the Bragg-peak position in ion therapy by means of single photon detection
M. Testa1, M. Bajard1, M. Chevallier1, D. Dauvergne1, P. Henriquet1, F. Le Foulher1, C. Ray1, E. Testa1, N. Freud2, J.M. Létang2, M.-H. Richard1, 2, S. Karkar3, R. Plescak, D. Schardt
(2010)

For real-time monitoring of the longitudinal position of the Bragg-peak during an ion therapy treatment, a novel non-invasive technique has been recently proposed that exploits the detection of prompt -rays issued from nuclear fragmentation. Two series of experiments have been performed at the GANIL and GSI facilities with 95 MeV/u and 305 MeV/u 12C6+ ion beams stopped in PMMA and water phantoms. In both experiments a clear correlation was obtained between the carbon ion range and the prompt photon profile. Additionally, an extensive study has been performed to investigate whether a prompt neutron component may be correlated with the carbon ion range. No such correlation was found. The present paper demonstrates that a collimated set-up can be used to detect single photons by means of time-of-flight measurements, at those high energies typical for ion therapy. Moreover, the applicability of the technique both at cyclotron and synchrotron facilities is shown. It is concluded that the detected photon count rates provide sufficiently high statistics to allow real-time control of the longitudinal position of the Bragg-peak under clinical conditions.
1 :  IPNL - Institut de Physique Nucléaire de Lyon
2 :  IMP-LMPB - Ingénierie des Matériaux Polymères-Laboratoire des Matériaux Polymères et des Biomatériaux
3 :  CPPM - Centre de Physique des Particules de Marseille
CAS-PHABIO
Physique/Physique/Physique Médicale

Physique/Physique Nucléaire Expérimentale

Physique/Physique/Instrumentations et Détecteurs
To be published in Radiation and Environmental Biophysics
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