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COST Chemistry CM0603-MELUSYN Joint Meeting, Paris : France (2010)
O2 and glutathione effects on water radiolysis: a simulation study
A. Colliaux1, 2, B. Gervais3, C. Rodriguez-Lafrasse4, M. Beuve1, 2

We present a MC simulation of water radiolysis when O2 and glutathione are present in the solution. Our simulation is based on the continuum approximation proposed by Green and co-workers'. We investigate in particular the sensitivity of the yield of HO2•+O2−• to the concentration of O2 and glutathione and to the LET of the ionising radiation. We demonstrate that the production of HO2•/O2−• is highly sensitive to these parameters and that the variation of their yield with the O2 concentration shares remarkable similarities with the O2 effect reported for biological cell damage efficiency .
1 :  IPNL - Institut de Physique Nucléaire de Lyon
2 :  LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
3 :  CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
4 :  Laboratoire de Radiobiologie Cellulaire et Moléculaire