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1st International Conference on Molecular Imaging Technology - EuroMedIm 2006, Marseille : France
Nuclear medical imaging using $\beta+\gamma$ coincidences from $^{44}$Sc radio-nuclide with liquid xenon as detection medium
C. Grignon1, J. Barbet2, M. Bardiès2, T. Carlier2, J.F. Chatal2, O. Couturier2, Jean-Pierre Cussonneau1, A. Faivre2, L. Ferrer2, S. Girault1, T. Haruyama, P. Le Ray1, L. Luquin1, S. Lupone1, V. Métivier1, E. Morteau1, N. Servagent1, D. Thers1
(2007)

We report on a new nuclear medical imaging technique based on the measurement of the emitter location in the three dimensions with a few mm spatial resolution using β+γ emitters. Such measurement could be realized thanks to a new kind of radio-nuclides which emit a γ-ray quasi-simultaneously with the β+ decay. The most interesting radio-nuclide candidate, namely 44Sc, will be potentially produced at the Nantes cyclotron ARRONAX. The principle is to reconstruct the intersection of the classical line of response (obtained with a standard PET camera) with the direction cone defined by the third γ-ray. The emission angle measurement of this additional γ-ray involves the use of a Compton telescope for which a new generation of camera based on a liquid xenon (LXe) time projection chamber is considered. GEANT3 simulations of a large acceptance LXe Compton telescope combined with a commercial micro-PET (LSO crystals) have been performed and the obtained results will be presented. They demonstrate that a good image can be obtained from the accumulation of each three-dimensional measured position. A spatial resolution of 2.3 mm has been reached with an injected activity of 0.5 MBq for a 44Sc point source emitter.
1 :  SUBATECH - Laboratoire SUBATECH Nantes
2 :  Recherches en cancérologie
Sciences du Vivant/Ingénierie biomédicale/Imagerie

Physique/Physique/Physique Médicale

Sciences du Vivant/Ingénierie biomédicale/Médecine nucléaire
Liquid xenon – Medical imaging – Scandium