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Prompt-gamma monitoring in hadrontherapy: A review

J. Krimmer 1, 2, 1, 2 D. Dauvergne 3, 3 J.M. Létang 4, 5, 4, 5 E. Testa 1, 1 
2 PRISME - PRISME
IP2I Lyon - Institut de Physique des 2 Infinis de Lyon
4 Imagerie Tomographique et Radiothérapie
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have been undertaken worldwide to promote prompt-gamma-based devices to be used in clinical conditions. Dedicated cameras are necessary to overcome the challenges of a broad- and high-energy distribution, a large background, high instantaneous count rates, and compatibility constraints with patient irradiation. Several types of prompt-gamma imaging devices have been proposed, that are either physically-collimated or electronically collimated (Compton cameras). Clinical tests are now undergoing. Meanwhile, other methods than direct prompt-gamma imaging were proposed, that are based on specific counting using either time-of-flight or photon energy measurements. In the present article, we make a review and discuss the state of the art for all techniques using prompt-gamma detection to improve the quality assurance in hadrontherapy.
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Submitted on : Thursday, June 23, 2022 - 1:39:52 PM
Last modification on : Saturday, September 24, 2022 - 2:44:05 PM

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J. Krimmer, D. Dauvergne, J.M. Létang, E. Testa. Prompt-gamma monitoring in hadrontherapy: A review. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Elsevier, 2018, 878, pp.58-73. ⟨10.1016/j.nima.2017.07.063⟩. ⟨hal-01585334⟩

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