Among the light nuclear clusters the alpha-particle is by far the strongest bound system and therefore expected to play a significant role in the dynamics of nuclei and the phases of nuclear matter. To systematically study the properties of the alpha-particle we have derived an effective four-body equation of the Alt-Grassberger-Sandhas (AGS) type that includes the dominant medium effects, i.e. self energy corrections and Pauli-blocking in a consistent way. The equation is solved utilizing the energy dependent pole expansion for the sub system amplitudes. We find that the Mott transition of an alpha-particle at rest differs from that expected from perturbation theory and occurs at approximately 1/10 of nuclear matter densities.