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Reconstructed human epidermis: A model to study the barrier function

Abstract : The use of in vitro reconstructed human epidermis (RHE) by the cosmetic and pharmaceutical industries is increasing because of its similar physiological mechanisms to native human skin. With the advent of ethic laws on animal experimentation, RHE provides an helpful alternative for the test of formulations. The aim of this study is to check that the RHE mineral status is comparable to that of human native skin by investigating the elemental distributions in the epidermis strata. In addition, possible deleterious effects of the transport on the epidermis ionic content were studied by nuclear microscopy.
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Contributor : Dominique Girod Connect in order to contact the contributor
Submitted on : Wednesday, May 11, 2005 - 4:54:40 PM
Last modification on : Monday, March 28, 2022 - 10:44:04 AM

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Yves Barbotteau, E. Gontier, P. Barberet, M. Cappadoro, B. de Wever, et al.. Reconstructed human epidermis: A model to study the barrier function. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Elsevier, 2005, 231, pp.286-291. ⟨10.1016/j.nimb.2005.01.072⟩. ⟨in2p3-00024129⟩



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