A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats - IN2P3 - Institut national de physique nucléaire et de physique des particules Access content directly
Journal Articles Physics in Medicine and Biology Year : 2013

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

Mathieu Benoit

Abstract

The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications to their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using a submillimetric probe for beta+ radiotracer detection based on a pixelated silicon diode that can be stereotaxically implanted in the brain region of interest. This fully autonomous detection system permits time-resolved high sensitivity measurements of radiotracerswith additional imaging features in freelymoving rats. An application-specific integrated circuit (ASIC) allows for parallel signal processing of each pixel and enables the wireless operation. All components of the detector were tested and characterized. The beta+ sensitivity of the system was determined with the probe dipped into radiotracer solutions.Monte Carlo simulations served to validate the experimental values and assess the contribution of gamma noise. Preliminary implantation tests on anaesthetized rats proved PIXSIC's functionality in brain tissue. High spatial resolution allows for the visualization of radiotracer concentration in different brain regions with high temporal resolution. (Some figures may appear in colour only in the online journal)

Domains

Bioengineering
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Dates and versions

in2p3-00837658 , version 1 (24-06-2013)

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Julia Maerk, Didier Benoit, Laure Balasse, Mathieu Benoit, Jean-Claude Clémens, et al.. A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats. Physics in Medicine and Biology, 2013, 58, pp.4483 - 4500. ⟨10.1088/0031-9155/58/13/4483⟩. ⟨in2p3-00837658⟩
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